Figure 4

Proposed model for host-pathogen interaction in porcine enterocytes infected with L. intracellularis . (A) Infected enterocyte. Apical membrane exhibiting down-regulation of genes involved in nutrient acquisition and electrolyte secretion (green) and up-regulation of copper uptake protein (red). Basolateral membrane exhibiting up-regulation of glucose transporter (SLC2A1) and MHC class I genes. (B) Intracellular bacterium. High expression (yellow) of genes included in the oxidative stress protection system: redox enzymes, Cu-Zn superoxide dismutase (sodC) and rubrerythrin-rubredoxin (rubY-rubA) operon (Adapted from Lumppio et al. 2001). Moderate expression genes encoding the basal body of the type III secretion system (TIIISS) (light yellow) and high expression of TIIISS effector proteins (PcrH-SseC-Sse? operon). Genetic organization and gene expression (log_{2 [RPKM]}) of the rubY-rubA and PcrH-SseC-Sse operons.