Table 2 The 20 most up-regulated genes in mouse macrophage cell line RAW 264.7 infected with each B. abortus compare to uninfected macrophage

Cxcl2

Chemokine (C-X-C motif) ligand 2

34.68

1.56E-193

21.51

1.54E-156

33.41

7.14E-220

43.82

5.67E-166

29.62

4.21E-205

Tnf

Tumor necrosis factor

17.47

4.45E-150

14.18

3.82E-133

21.83

1.58E-168

22.45

6.39E-120

18.35

3.46E-157

Nfkbiz

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

15.58

3.68E-118

11.51

1.42E-100

18.61

3.69E-151

17.88

3.63E-96

14.34

1.80E-128

Irg1

Immunoresponsive gene 1

12.29

2.47E-99

8.82

9.26E-80

10.29

4.04E-96

14.74

1.45E-83

11.29

1.04E-106

Ier3

Immediate early response 3

8.35

4.93E-82

6.36

1.01E-63

9.03

7.44E-87

9.04

1.02E-55

7.6

2.81E-78

Traf1

NOD-derived CD11c + ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630118K07 product: Tnf receptor-associated factor 1, full insert sequence

8.13

5.31E-56

5.68

3.78E-37

7.3

1.67E-58

9.22

1.21E-56

7.54

1.42E-66

Phlda1

Pleckstrin homology-like domain, family A, member 1

6.56

3.88E-53

5.04

8.66E-43

6.97

4.86E-67

7.27

3.88E-45

6.49

9.56E-62

Gpr84

G protein-coupled receptor 84

6.30

9.74E-59

5.36

2.85E-50

6.74

1.83E-64

7..45

1.48E-45

6.48

1.31E-67

Ccl2

Chemokine (C-C motif) ligand 2

6.16

4.74E-50

4.03

1.50E-31

5.2

2.46E-48

6.16

9.30E-38

5.14

3.57E-47

Ccl7

Chemokine (C-C motif) ligand 7

5.26

8.97E-32

3.48

2.07E-18

3.68

7.03E-21

5.91

5.23E-36

4.85

1.48E-39

Il1b

Interleukin 1 beta

4.89

2.78E-26

2.87

5.56E-13

3.63

2.88E-20

6.12

1.95E-37

4.29

6.18E-33

Gpr109a

Niacin receptor 1

4.45

2.13E-23

3.31

5.81E-17

3.73

4.66E-21

5.38

3.27E-32

4.43

8.81E-35

Cish

Cytokine inducible SH2-containing protein

4.43

4.39E-23

3.0

3.85E-14

3.83

6.24E-22

5.35

5.20E-32

4.21

2.63E-32

Marcksl1

MARCKS-like 1

4.32

2.26E-29

3.29

6.83E-19

4.27

1.75E-35

4.76

1.14E-27

4.27

2.45E-35

Cd83

CD83 antigen

4.01

7.25E-26

3.31

4.48E-19

4.32

3.18E-36

4.47

1.92E-25

3.94

2.74E-31

Il4i1

Interleukin 4 induced 1

4.0

3.19E-20

3.11

4.16E-15

3.64

2.06E-20

4.56

4.58E-26

3.88

8.18E-29

Socs3

Suppressor of cytokine signaling 3

3.66

1.95E-20

2.45

3.55E-09

3.78

1.80E-26

4.93

6.06E-29

3.05

1.49E-19

Nfkbia

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

3.58

1.78E-22

3.34

2.00E-21

4.25

1.50E-36

4.46

2.12E-25

3.73

2.96E-29

Edn1

Endothelin 1

3.53

2.85E-16

2.28

8.95E-08

2.49

5.74E-10

3.51

1.20E-17

2.84

1.34E-15

Ehd1

EH-domain containing 1

3.45

8.17E-17

2.83

1.43E-12

3.22

2.12E-17

4.01

1.02E-21

3.5

1.30E-24