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Table 2 The 20 most up-regulated genes in mouse macrophage cell line RAW 264.7 infected with each B. abortus compare to uninfected macrophage

From: Early transcriptional responses of internalization defective Brucella abortus mutants in professional phagocytes, RAW 264.7

Gene symbol Description 1119-3 C10 C29 D6 D7
   FC P-value FC P-value FC P-value FC P-value FC P-value
Cxcl2 Chemokine (C-X-C motif) ligand 2 34.68 1.56E-193 21.51 1.54E-156 33.41 7.14E-220 43.82 5.67E-166 29.62 4.21E-205
Tnf Tumor necrosis factor 17.47 4.45E-150 14.18 3.82E-133 21.83 1.58E-168 22.45 6.39E-120 18.35 3.46E-157
Nfkbiz Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 15.58 3.68E-118 11.51 1.42E-100 18.61 3.69E-151 17.88 3.63E-96 14.34 1.80E-128
Irg1 Immunoresponsive gene 1 12.29 2.47E-99 8.82 9.26E-80 10.29 4.04E-96 14.74 1.45E-83 11.29 1.04E-106
Ier3 Immediate early response 3 8.35 4.93E-82 6.36 1.01E-63 9.03 7.44E-87 9.04 1.02E-55 7.6 2.81E-78
Traf1 NOD-derived CD11c + ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630118K07 product: Tnf receptor-associated factor 1, full insert sequence 8.13 5.31E-56 5.68 3.78E-37 7.3 1.67E-58 9.22 1.21E-56 7.54 1.42E-66
Phlda1 Pleckstrin homology-like domain, family A, member 1 6.56 3.88E-53 5.04 8.66E-43 6.97 4.86E-67 7.27 3.88E-45 6.49 9.56E-62
Gpr84 G protein-coupled receptor 84 6.30 9.74E-59 5.36 2.85E-50 6.74 1.83E-64 7..45 1.48E-45 6.48 1.31E-67
Ccl2 Chemokine (C-C motif) ligand 2 6.16 4.74E-50 4.03 1.50E-31 5.2 2.46E-48 6.16 9.30E-38 5.14 3.57E-47
Ccl7 Chemokine (C-C motif) ligand 7 5.26 8.97E-32 3.48 2.07E-18 3.68 7.03E-21 5.91 5.23E-36 4.85 1.48E-39
Il1b Interleukin 1 beta 4.89 2.78E-26 2.87 5.56E-13 3.63 2.88E-20 6.12 1.95E-37 4.29 6.18E-33
Gpr109a Niacin receptor 1 4.45 2.13E-23 3.31 5.81E-17 3.73 4.66E-21 5.38 3.27E-32 4.43 8.81E-35
Cish Cytokine inducible SH2-containing protein 4.43 4.39E-23 3.0 3.85E-14 3.83 6.24E-22 5.35 5.20E-32 4.21 2.63E-32
Marcksl1 MARCKS-like 1 4.32 2.26E-29 3.29 6.83E-19 4.27 1.75E-35 4.76 1.14E-27 4.27 2.45E-35
Cd83 CD83 antigen 4.01 7.25E-26 3.31 4.48E-19 4.32 3.18E-36 4.47 1.92E-25 3.94 2.74E-31
Il4i1 Interleukin 4 induced 1 4.0 3.19E-20 3.11 4.16E-15 3.64 2.06E-20 4.56 4.58E-26 3.88 8.18E-29
Socs3 Suppressor of cytokine signaling 3 3.66 1.95E-20 2.45 3.55E-09 3.78 1.80E-26 4.93 6.06E-29 3.05 1.49E-19
Nfkbia Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 3.58 1.78E-22 3.34 2.00E-21 4.25 1.50E-36 4.46 2.12E-25 3.73 2.96E-29
Edn1 Endothelin 1 3.53 2.85E-16 2.28 8.95E-08 2.49 5.74E-10 3.51 1.20E-17 2.84 1.34E-15
Ehd1 EH-domain containing 1 3.45 8.17E-17 2.83 1.43E-12 3.22 2.12E-17 4.01 1.02E-21 3.5 1.30E-24