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Table 2 Classification of primary and secondary gastrin induced genes lower expressed in transiently treated cells

From: The duration of gastrin treatment affects global gene expression and molecular responses involved in ER stress and anti-apoptosis

  Primary genes1(N=115) Secondary genes2(N=48)
Fraction
Per cent (%) genes in each group: 100 90 70 74 65 40 0 10 9 7 30 50
Temporal profiles 3 a b c d e f a b c d e f
Molecular function 4 ( N=163) 5 9 16 20 48 17 0 1 2 2 22 21
Regulation of gene expression (N=22) 3 1 6 7 0 1 0 0 0 2 1 1
 Transcription factors 3 0 3 5 0 0 0 0 0 0 0 1
 Co-transcription factors 0 1 3 2 0 1 0 0 0 2 1 0
Signal transduction (N=44) 0 4 4 7 15 4 0 0 1 0 5 4
 Receptors 0 0 0 2 1 1 0 0 0 0 1 0
 Ligands 0 0 2 1 6 2 0 0 1 0 1 2
 Intracellular signalling proteins 0 4 2 4 8 1 0 0 0 0 3 2
Transporters (N=15) 0 2 0 1 7 0 0 0 1 0 1 3
 Channel and/or ER related 0 1 0 1 6 0 0 0 1 0 0 3
 Other transporters 0 1 0 0 1 0 0 0 0 0 1 0
Protein Binding (N=23) 0 1 1 2 9 3 0 0 0 0 2 4
 Chaperone activity 0 1 0 0 1 1 0 1 0 0 1 4
 Other protein binding 0 0 1 2 8 2 0 0 0 0 1 0
Enzymes (N=39) 0 0 2 1 11 6 0 0 0 0 11 8
 Proteases 0 0 2 0 4 1 0 0 0 0 0 6
 Aminoacyl tRNA synthases 0 0 0 0 0 0 0 0 0 0 6 0
 Other enzymes 0 0 0 1 7 5 0 0 0 0 5 2
Other functions (N=20) 2 1 3 2 6 3 0 0 0 0 2 1
  1. 1 Genes independent on de novo protein synthesis for gastrin induced expression (115 of 181 selected genes); 2 Genes dependent on de novo protein synthesis for gastrin induced expression (48 of 181 selected genes); number of uncertain genes: N= 18; 3 Temporal profiles are illustrated in Figure 5; 4Molecular functions are defined based on data from MetaCore tool of GeneGo package [15] Gene Ontology Annotation (UniProt-GOA) Database GOA [38] and literature.