Genetic variability of mutans streptococci revealed by wide whole-genome sequencing

Song, Lifu; Wang, Wei; Conrads, Georg; Rheinberg, Anke; Sztajer, Helena; Reck, Michael; Wagner-Döbler, Irene; Zeng, An-Ping

doi:10.1186/1471-2164-14-430

BMC Genomics

Table 3 Distribution of competence development-related systems in the 10 mutans streptococci strains

From: Genetic variability of mutans streptococci revealed by wide whole-genome sequencing

Name	Function	S. mutans	S. mutans	S. mutans	S. mutans	S. mutans	S. mutans	S. mutans	S. mutans	S. ratti	S. sobrinus
Name	Function	UA159	NN2025	5DC8	KK21	KK23	AC4446	ATCC 25175	NCTC 11060	DSM 20564	DSM 20742
ComA/	Competence factor & nonlantibiotic mutacin transporting ATP-binding/permease protein	SMU.286	GI\|290581206	D816_01150	D817_01300	D818_01134	D819_01163	D820_01336	D821_01208	D822_01584	D823_05343
ComA/		SMU.1881c	GI\|290579788	D816_08453	D817_08643	-	D819_07724		D821_08449	D822_08325-	D823_01400
NlmT		SMU.1881c	GI\|290579788	D816_08453	D817_08643	-	D819_07724		D821_08449	D822_08325-	D823_01400
ComB/	Accessory factor for NlmT	SMU.287	GI\|290581205	D816_01155	D817_01305	D818_01139	D819_01168	D820_01341	D821_01213	D822_01589	D823_05923
NlmE	Accessory factor for NlmT	SMU.287	GI\|290581205	D816_01155	D817_01305	D818_01139	D819_01168	D820_01341	D821_01213	D822_01589	D823_05923
ComC	S. mutans specific competence stimulating peptide, precursor	SMU.1915	GI\|290579762	D816_08588	D817_08778	D818_08368	D819_07839	D820_08520	D821_08549	-	-
SepM	cell surface-associated protease; Cleavage CSP.	SMU.518	GI\|290580977	D816_02205	D817_02448	D818_02735	D819_02254	D820_02420	D821_02274	D822_04126	D823_08607
ComD	histidine kinase	SMU.1916	GI\|290579761	D816_08593	D817_08783	D818_08373	D819_07844	D820_08525	D821_08554		D823_05333
ComE	response regulator	SMU.1917	GI\|290579760	D816_08598	D817_08788	D818_08378	D819_07849	D820_08530	D821_08559		D823_05328
ComE	response regulator	SMU.1917	GI\|290579760	D816_08598	D817_08788	D818_08378	D819_07849	D820_08530	D821_08559		D823_7992
HtrA	serine protease	SMU.2164	GI\|290581420	D816_09733	D817_00015 D817_09913	D818_00020	D819_09056	D820_09650	D821_09748	D822_05851	D823_03191
HdrM	high density responsive membrane protein	SMU.1855	GI\|290579809	D816_08353	D817_08543	D818_08143	D819_07614	D820_08345	D821_08319	D822_08240	D823_08222
HdrR	high density responsive regulator	SMU.1854	GI\|290579810	D816_08348	D817_08538	D818_08138	D819_07609	D820_08340	D821_08314	-	-
BrsM		SMU.2081	GI\|290581347	D816_09358	D817_09538	D818_09198	D819_08671	D820_09275	D821_09348	-	-
BrsR		SMU.2080	GI\|290581346	D816_09353	D817_09533	D818_09193	D819_08666	D820_09270	D821_09343	D822_05085	-
OppD	oligopeptide ABC transporter	SMU.258	GI\|290581226	D816_01025	D817_01175	D818_01039	D819_01063	D820_01211	D821_01051	D822_05611	D823_04322
ComS	comX-inducing peptide (XIP) precursor	NC_004350.2	NC_013928.1	D816_00277	D817_00297	D818_00297	D819_00203	D820_00247	D821_00253	D822_01077	-
ComS	comX-inducing peptide (XIP) precursor	(62613 - 62666)a	(60952- 61005)b	D816_00277	D817_00297	D818_00297	D819_00203	D820_00247	D821_00253	D822_01077	-
ComR	ComS receptor	SMU.61	GI\|290579576	D816_00275	D817_00295	D818_00294	D819_00200	D820_00245	D821_00250	D822_01080
ComX(SigX)	competence-specific sigma factor	SMU.1997	GI\|290579687	D816_08973	D817_09163	D818_08748	D819_08219	D820_08900	D821_08929	D822_07328	D823_08887
ComEA	competence protein	SMU.625	GI\|290580890	D816_02675	D817_02923	D818_03217	D819_02694	D820_02880	D821_02784	D822_02674	D823_08107
ComEC	competence protein; possible integral membrane protein	SMU.626	GI\|290580889	D816_02680	D817_02928	D818_03222	D819_02699	D820_02885	D821_02789	D822_02679	D823_08117
CoiA	competence protein CoiA	SMU.644	GI\|290580870	D816_02775	D817_03018	D818_03322	D819_02786	D820_02970	D821_02879	D822_02739	D823_01025
EndA	competence associated membrane nuclease (DNA-entry nuclease)	SMU.1523	GI\|290580108	D816_06842	D817_07008	D818_06659	D819_06647	D820_06860	D821_06857	D822_03254	D823_09687
ComG	competence protein G	SMU.1981c	GI\|290579702	D816_08898	D817_09088	D818_08673	D819_08144	D820_08825	D821_08854	D822_07418	D823_01170
ComYD	competence protein ComYD	SMU.1983	GI\|290579700	D816_08908	D817_09098	D818_08683	D819_08154	D820_08835	D821_08864	D822_07408	D823_01160
ComYC	competence protein ComYC	SMU.1984	GI\|290579699	D816_08913	D817_09103	D818_08688	D819_08159	D820_08840	D821_08869	D822_07403	D823_01155
	possible competence-induced protein	SMU.2075c	GI\|290581342	D816_09328	D817_09508	D818_09168	D819_08641	D820_09245	D821_09318	D822_05110	D823_03558
CinA	competence damage-inducible protein A	SMU.2086	GI\|290581351	D816_09383	D817_09563	D818_09218	D819_08691	D820_09295	D821_09368	D822_05060	D823_03593
ComYB	competence protein; general (type II) secretory pathway protein	SMU.1985	GI\|290579698	D816_08918	D817_09108	D818_08693	D819_08164	D820_08845	D821_08874	D822_07398	D823_01150
ComYA	late competence protein; type II secretion system protein	SMU.1987	GI\|290579697	D816_08923	D817_09113	D818_08698	D819_08169	D820_08850	D821_08879	D822_07393	D823_01145
ComFC	late competence protein required for DNA uptake	SMU.499	GI\|290580999	D816_02100	D817_02348	D818_02650	D819_02154	D820_02290	D821_02159	D822_06218	D823_02981
ComFA	late competence protein F	SMU.498	GI\|290581000	D816_02095	D817_02343	D818_02645	D819_02149	D820_02285	D821_02154	D822_06223	D823_02986
CinA	competence damage-inducible protein A;	SMU.2086	GI\|290581351	D816_09383	D817_09563	D818_09218	D819_08691	D820_09295	D821_09368	D822_05060	D823_03593

In the case that more than one paralogs were found, the most similar ortholog is marked in italic. The rows related to highly conserved ‘late-competence genes’ were shown in boldface. The missing of ComDE in S. ratti DSM 20564 has been published in our previous study [26].
^alocation of comS in S. mutans UA159.
^blocation of comS in S. mutans NN2025.

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ISSN: 1471-2164

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