Network view of TGF-beta signaling pathway alterations in colorectal and ovarian cancer. (A) Network view of genes altered by copy number changes in colorectal cancer in the TGF-beta signaling pathway (diamond nodes) or genes directly interacting with TGF-beta signaling genes (circular nodes) based on the protein-protein interaction database. (B) The same network view for ovarian cancer. Size of node represents frequency of amplification or deletion in patient population. Color of node indicates whether gene is amplified (red), deleted (green), or unchanged (gray). Lines indicate interactions. Blue dotted line separates genes within the pathway from genes that interact with the pathway based on the protein-protein interaction database.