WGCNA co-expression modules. (A) WGCNA modules were constructed based on the Topological Overlap Matrix. This is an example displaying the topology of the magenta module. Nodes are genes, and the size of node is proportional to its contribution in forming this module. Width of the edges is proportional to strength of correlation between two connected genes. (B) Table showing the contribution of all member genes to the formation of the magenta module. (C) Clustering of the 76 modules shows as a 76 by 76 heat map matrix resulted from bi-clustering based on the module eigenvectors. The eigenvector of the expression matrix for each module was used to represent its expression profile. Each row or column is one module, and the color in each small cell describes the relationship between two modules. Yellow shades indicate positive correlations (i.e., similar expression profiles) between two modules, whereas blue shades mean anti-correlations. Black indicates no correlation.