Table 3 N. apis s equences that show homology to annotated and experimentally verified pathogenicity and virulence genes of microsporidia species

1) Polar Tube Protein

PTP2

NAPIS-00435

Yes

N. bombycis

[77]

PTP3

NAPIS-01921

Host cell invasion

Yes

N. bombycis

[77]

PTP3

NAPIS-01922

Yes

N. bombycis

[77]

2) Spore Wall Protein

SWP12

NAPIS-00521

Yes

N. bombycis

[78]

SWP25

NAPIS-00461

Yes

N. bombycis

[79]

NAPIS-00514

Structural capacity &

Yes

N. bombycis

[79]

NAPIS-01092

host cell adhesion

Yes

N. bombycis

[79]

SWP26

NAPIS-00203

Yes

N. bombycis

[80]

SWP32

NAPIS-00269

Yes

N. bombycis

[78]

3) Endochitinase

NAPIS-02055

Spore attachment

Yes

E. hellem

[56]

NAPIS-02138

No

E. hellem

[56]

4) Chitin synthase

NAPIS-01775

Spore attachment

Yes

E. intestinalis

[53]

NAPIS-02139

& pathogenicity

Yes

E. hellem

[56]

6) Mitogen-activated protein kinase

NAPIS-01928

Pathogenicity Regulation

Yes

E. intestinalis

[53]

7) ATP/ADP Translocase

NAPIS-01593

Yes

E. cuniculi

[50]

NAPIS-01593

Energy parasitism

Yes

E. cuniculi

[50]

NAPIS-02128

Yes

E. cuniculi

[50]

NAPIS-02287

Yes

E. cuniculi

[50]

8) Transferase

NAPIS-00457

No

E. hellem

[56]

NAPIS-00459

Pathogenicity

Yes

E. cuniculi

[50]

NAPIS-00459

regulation

Yes

E. intestinalis

[53]

NAPIS-00578

No

E. hellem

[56]

NAPIS-00596

Yes

E. hellem

[56]

9) Splicing machinery

NAPIS-00564

Yes

E. intestinalis

[53]

NAPIS-00654

Pathogenicity

Yes

E. intestinalis

[53]

NAPIS-01012

regulation

Yes

E. hellem

[56]

NAPIS-02190

Yes

E. romaleae

[56]