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Table 3 Gene classification according to canonical signalling pathways* using IPA

From: Transcriptome analysis of porcine M. semimembranosus divergent in intramuscular fat as a consequence of dietary protein restriction

Ingenuity® Canonical Pathways

P-value

% DE#

Genes

Factors Promoting Cardiogenesis in Vertebrates

0.0021

8.51

TGFBR2, CCNE1, TGFB2, LEF1, TCF7L1, APC, PRKD1, CDK2

Antiproliferative Role of TOB in T Cell Signalling

0.0047

15.4

TGFBR2, CCNE1,TGFB2, CDK2

Alanine and Aspartate Metabolism

0.0061

5.68

ADSL, ASNSD1, DARS, MYO5B, ASNS

HIF1α Signalling

0.0066

7.27

MAPK8, MRAS, KRAS, MMP2, HIF1A, MMP24, NOS2, P4HTM

Nicotinate and Nicotinamide Metabolism

0.018

5.15

NT5C3, DAPK1, ENPP1, NEK2, MAPK8, MAK, CDK2

Apoptosis Signalling

0.025

6.67

CAPNS1, MAPK8, MRAS, KRAS, MAP4K4, PARP1

PPARα/RXRα Activation

0.031

5

TGFBR2, GPD1, MAPK8, MRAS, TGFB2, KRAS, MAP4K4, CYP2C19, ITGB5

Arachidonic Acid Metabolism

0.037

3.57

PLA2G4A, GPX3, CYP4B1, GPX5, ALOX12, CYP2C19, GPX6, PLOD3

Nitrogen Metabolism

0.039

3.01

CA9, CA3, ASNSD1, ASNS

Prolactin Signalling

0.039

6.49

SOCS3, SP1, MRAS, KRAS, PRKD1

p38 MAPK Signalling

0.043

6.25

TGFBR2, PLA2G4A, DDIT3, TGFB2, CREB3L4, HMGN1

ATM Signalling

0.047

7.55

CCNB1, MAPK8, CREB3L4, CDK2

NF-κB Activation by Viruses

0.048

6.00

CR2, ITGB5, KRAS, MRAS, PRKD1

Intrinsic Prothrombin Activation Pathway

0.049

8.60

COL3A1, COL5A3, PROS1

HGF Signalling

0.049

5.71

MAPK8, MRAS, KRAS, MAP3K3, PRKD1, CDK2

TGF-β Signalling

0.054

6.00

KRAS, MAPK8, MRAS, TGFB2, TGFBR2

  1. #% DE: Percentage of genes annotated in that pathway that were observed differentially expressed in the present study.
  2. *Cancer, disease-specific pathways, neurotransmitter and other nervous system signalling and pathogen-influenced signalling were excluded from the analysis.
  3. Down-regulated genes are highlighted in bold, up-regulated genes are in normal typeface.