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Table 3 The most significant changes in expression of genes involved in cell death regulation

From: Impact of heat shock transcription factor 1 on global gene expression profiles in cells which induce either cytoprotective or pro-apoptotic response following hyperthermia

Entrez gene ID Mean SC_C Mean SC_38 SLR SC_38 vs C Mean HEP_C Mean HEP_43 SLR HEP_43 vs C Gene symbol (full name) Function
76747 6.80 8.31 1.51 4.82 4.48 −0.33 Dapl1 (death associated protein-like 1) Role in the early stages of epithelial differentiation or in apoptosis
236312 6.99 8.16 1.17 5.30 5.33 0.03 Pyhin1 (pyrin and HIN domain family, member 1) Promotes ubiquitination and subsequent degradation of MDM2
234463 8.55 9.68 1.13 7.70 7.88 0.18 Tmem184c (transmembrane protein 184C) Inhibitor of cell growth
50996 7.67 6.00 −1.68 5.56 5.95 0.39 Pdcd7 (programmed cell death 7) May be selectively involved in specific apoptotic processes in mouse T-cells
75736 8.89 7.25 −1.64 6.35 6.17 −0.18 Bcl2l12 (BCL2-like 12 (proline rich) Potent apoptotic inhibitor
11800 7.85 6.32 −1.53 7.78 7.76 −0.02 Api5 (apoptosis inhibitor 5) Prevents apoptosis after growth factor deprivation.
74126 8.08 6.90 −1.17 9.56 9.45 −0.11 Syvn1 (synovial apoptosis inhibitor 1, synoviolin) Protects cells from ER stress-induced apoptosis
69928 6.41 5.43 −0.99 4.58 4.55 −0.03 Apitd1 (apoptosis-inducing, TAF9-like domain 1) Cell growth and/or cell death properties in neuroblastoma cells
29810 8.73 8.47 −0.25 8.93 12.59 3.67 Bag3 (BCL2-associated athanogene 3) Anti-apoptotic activity
237436 nl nl - 4.38nl 6.31 1.93 Gas2l3 (growth arrest-specific 2 like 3) Microtubule-actin cross-linking protein
21664 nl nl - 11.41 12.95 1.54 Phlda1 (pleckstrin homology-like domain, family A, member 1) Regulation of apoptosis
17210 7.87 6.97 −0.90 9.02 10.06 1.04 Mcl1 (myeloid cell leukemia sequence 1) Regulation of apoptosis
21929 5.52 5.52 0.00 5.43 6.42 0.99 Tnfaip3 (tumor necrosis factor, alpha-induced protein 3) Inhibitor of programmed cell death
17873 6.02 6.36 0.34 5.79 6.75 0.95 Gadd45b (growth arrest and DNA-damage-inducible 45 beta) Regulation of growth and apoptosis
23882 5.11 5.65 0.54 8.93 7.71 −1.22 Gadd45g (growth arrest and DNA-damage-inducible 45 gamma) Regulation of growth and apoptosis
  1. The level of expression in spermatocytes (SC) and hepatocytes (HEP) is given in arbitrary units in logarithmic scale (log2). Changes in gene expression after hyperthermia (at 38°C or 43°C) are shown as SLRs.
  2. nl noise level.