Table 3 The most significant changes in expression of genes involved in cell death regulation
Entrez gene ID | Mean SC_C | Mean SC_38 | SLR SC_38 vs C | Mean HEP_C | Mean HEP_43 | SLR HEP_43 vs C | Gene symbol (full name) | Function |
|---|---|---|---|---|---|---|---|---|
76747 | 6.80 | 8.31 | 1.51 | 4.82 | 4.48 | −0.33 | Dapl1 (death associated protein-like 1) | Role in the early stages of epithelial differentiation or in apoptosis |
236312 | 6.99 | 8.16 | 1.17 | 5.30 | 5.33 | 0.03 | Pyhin1 (pyrin and HIN domain family, member 1) | Promotes ubiquitination and subsequent degradation of MDM2 |
234463 | 8.55 | 9.68 | 1.13 | 7.70 | 7.88 | 0.18 | Tmem184c (transmembrane protein 184C) | Inhibitor of cell growth |
50996 | 7.67 | 6.00 | −1.68 | 5.56 | 5.95 | 0.39 | Pdcd7 (programmed cell death 7) | May be selectively involved in specific apoptotic processes in mouse T-cells |
75736 | 8.89 | 7.25 | −1.64 | 6.35 | 6.17 | −0.18 | Bcl2l12 (BCL2-like 12 (proline rich) | Potent apoptotic inhibitor |
11800 | 7.85 | 6.32 | −1.53 | 7.78 | 7.76 | −0.02 | Api5 (apoptosis inhibitor 5) | Prevents apoptosis after growth factor deprivation. |
74126 | 8.08 | 6.90 | −1.17 | 9.56 | 9.45 | −0.11 | Syvn1 (synovial apoptosis inhibitor 1, synoviolin) | Protects cells from ER stress-induced apoptosis |
69928 | 6.41 | 5.43 | −0.99 | 4.58 | 4.55 | −0.03 | Apitd1 (apoptosis-inducing, TAF9-like domain 1) | Cell growth and/or cell death properties in neuroblastoma cells |
29810 | 8.73 | 8.47 | −0.25 | 8.93 | 12.59 | 3.67 | Bag3 (BCL2-associated athanogene 3) | Anti-apoptotic activity |
237436 | nl | nl | - | 4.38nl | 6.31 | 1.93 | Gas2l3 (growth arrest-specific 2 like 3) | Microtubule-actin cross-linking protein |
21664 | nl | nl | - | 11.41 | 12.95 | 1.54 | Phlda1 (pleckstrin homology-like domain, family A, member 1) | Regulation of apoptosis |
17210 | 7.87 | 6.97 | −0.90 | 9.02 | 10.06 | 1.04 | Mcl1 (myeloid cell leukemia sequence 1) | Regulation of apoptosis |
21929 | 5.52 | 5.52 | 0.00 | 5.43 | 6.42 | 0.99 | Tnfaip3 (tumor necrosis factor, alpha-induced protein 3) | Inhibitor of programmed cell death |
17873 | 6.02 | 6.36 | 0.34 | 5.79 | 6.75 | 0.95 | Gadd45b (growth arrest and DNA-damage-inducible 45 beta) | Regulation of growth and apoptosis |
23882 | 5.11 | 5.65 | 0.54 | 8.93 | 7.71 | −1.22 | Gadd45g (growth arrest and DNA-damage-inducible 45 gamma) | Regulation of growth and apoptosis |