Table 4 Selected transcriptional regulators differentially expressed after hyperthermia
Entrez gene ID | Mean SC_C | Mean SC_38 | SLR SC_38 vs C | Mean HEP_C | Mean HEP_43 | SLR HEP_43 vs C | Gene symbol (full name) |
|---|---|---|---|---|---|---|---|
A. Induced in spermatocytes, heat shock 38°C | |||||||
224694 | 4.30nl | 5.82 | 1.52 | nl | nl | - | Zfp81 (zinc finger protein 81) |
16600 | 8.78 | 10.28 | 1.49 | 5.18 | 5.67 | 0.49 | Klf4 (Kruppel-like factor 4 (gut) |
22768 | 4.37 | 5.62 | 1.26 | nl | nl | - | Zfy2 (zinc finger protein 2, Y linked) |
73503 | 9.13 | 10.34 | 1.21 | 4.91 | 5.16 | 0.25 | Mbd3l1 (methyl-CpG binding domain protein 3-like 1) |
208727 | 5.29 | 6.49 | 1.19 | 4.55 | 4.65 | 0.09 | Hdac4 (histone deacetylase 4) |
54427 | 6.77 | 7.95 | 1.19 | 5.62 | 5.10 | −0.52 | Dnmt3l (DNA (cytosine-5-)-methyltransferase 3-like) |
12224 | 8.22 | 9.39 | 1.17 | 4.91 | 4.64 | −0.27 | Klf5 (Kruppel-like factor 5) |
56381 | 7.18 | 8.30 | 1.12 | 6.15 | 6.04 | −0.11 | Spen (SPEN homolog, transcriptional regulator (Drosophila)) |
75753 | 6.08 | 7.15 | 1.07 | 5.12 | 5.42 | 0.30 | Klf17 (Kruppel-like factor 17) |
16870 | 6.10 | 7.16 | 1.06 | 4.96 | 4.92 | −0.04 | Lhx2 (LIM homeobox protein 2) |
16601 | 7.21 | 8.27 | 1.06 | 8.39 | 8.31 | −0.08 | Klf9 (Kruppel-like factor 9) |
18132 | 5.99 | 7.04 | 1.05 | nl | nl | - | Notch4 (Notch gene homolog 4 (Drosophila)) |
56706 | 8.61 | 9.62 | 1.01 | 8.57 | 9.17 | 0.60 | Ccnl1(cyclin L1) |
B. Repressed in spermatocytes, heat shock 38°C | |||||||
60406 | 9.25 | 6.78 | −2.47 | 6.10 | 6.20 | 0.10 | Sap30 (sin3 associated polypeptide) |
74197 | 8.42 | 6.14 | −2.28 | 6.83 | 7.04 | 0.21 | Gtf2e1 (general transcription factor II E, polypeptide 1 (alpha subunit)) |
209707 | 7.30 | 5.26 | −2.04 | 4.54 | 4.85 | 0.31 | Lcorl (ligand dependent nuclear receptor corepressor-like) |
15904 | 8.88 | 6.88 | −2.00 | 4.79 | 4.84 | 0.05 | Id4 (inhibitor of DNA binding 4) |
71041 | 9.77 | 7.93 | −1.83 | 6.81 | 7.13 | 0.32 | Pcgf6 (polycomb group ring finger 6) |
26919 | 8.66 | 6.89 | −1.77 | 6.16 | 6.55 | 0.40 | Zfp346 (zinc finger protein 346) |
319944 | 6.84 | 5.12 | −1.73 | 5.53 | 5.44 | −0.09 | Taf2 (TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor) |
22702 | 6.88 | 5.22 | −1.66 | nl | nl | - | Zfp42 (zinc finger protein 428) |
231329 | 8.77 | 7.34 | −1.43 | 9.50 | 9.33 | −0.17 | Polr2b (polymerase (RNA) II (DNA directed) polypeptide B) |
102334 | 7.95 | 6.48 | −1.47 | 5.90 | 6.18 | 0.28 | Ankrd10 (ankyrin repeat domain 10) |
78912 | 6.92 | 5.55 | −1.38 | 5.94 | 5.88 | −0.06 | Sp2 (Sp2 transcription factor) |
19009 | 7.02 | 5.69 | −1.33 | 4.81 | 4.79 | −0.01 | Pou6f1 (POU domain, class 6, transcription factor 1) |
20687 | 4.86 | 3.58 | −1.29 | 7.14 | 7.07 | −0.08 | Sp3 (trans-acting transcription factor 3) |
75507 | 9.42 | 8.19 | −1.22 | 8.05 | 7.90 | −0.15 | Pou5f2 (POU domain class 5, transcription factor 2) |
100683 | 7.50 | 6.29 | −1.21 | 6.94 | 6.84 | −0.10 | Trrap (transformation/transcription domain-associated protein) |
22632 | 8.75 | 7.60 | −1.15 | 9.01 | 9.33 | 0.32 | Yy1 (YY1 transcription factor) |
16476 | 5.86 | 4.75 | −1.11 | 8.41 | 12.47 | 4.07 | Jun (Jun oncogene) |
14581 | 5.65 | 4.54 | −1.11 | nl | nl | - | Gfi1(growth factor independent 1) |
23894 | 7.29 | 6.20 | −1.09 | 6.27 | 6.25 | −0.02 | Gtf2h2 (general transcription factor II H, polypeptide 2) |
C. Induced in hepatocytes, heat shock 43°C | |||||||
11910 | 6.38 | 5.87 | −0.51 | 6.44 | 10.80 | 4.36 | Atf3 (activating transcription factor 3) |
16476 | 5.86 | 4.75 | −1.11 | 8.41 | 12.47 | 4.07 | Jun (Jun oncogene) |
23849 | nl | nl | - | 4.63 | 7.55 | 2.92 | Klf6 (Kruppel-like factor 6) |
14281 | 7.52 | 6.81 | −0.71 | 9.38 | 11.94 | 2.56 | Fos (FBJ osteosarcoma oncogene) |
13653 | 7.50 | 7.65 | 0.15 | 10.66 | 13.03 | 2.38 | Egr1 (early growth response 1) |
215418 | 7.41 | 7.10 | −0.31 | 7.23 | 9.28 | 2.05 | Csrnp1 (cysteine-serine-rich nuclear protein 1) |
80859 | 5.12 | 4.92 | −0.20 | 6.08 | 7.91 | 1.83 | Nfkbiz (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta) |
18030 | nl | nl | - | 6.28 | 7.99 | 1.71 | Nfil3 (nuclear factor, interleukin 3, regulated) |
15370 | 9.23 | 9.66 | 0.43 | 8.51 | 10.21 | 1.69 | Nr4a1 (nuclear receptor subfamily 4, group A, member 1) |
16477 | 5.86 | 5.44 | −0.42 | 8.31 | 9.90 | 1.59 | Junb (Jun-B oncogene) |
12053 | 4.86 | 5.17 | 0.31 | 5.74 | 7.05 | 1.31 | Bcl6 (B-cell leukemia/lymphoma 6) |
15982 | 6.92 | 7.31 | 0.40 | 7.22 | 8.41 | 1.20 | Ifrd1 (interferon-related developmental regulator 1) |
12192 | 6.09 | 7.03 | 0.94 | 10.05 | 11.26 | 1.21 | Zfp36l1 (zinc finger protein 36, C3H type-like 1) |
13654 | nl | nl | - | 4.09nl | 5.28 | 1.19 | Egr2 (early growth response 2) |
17133 | 4.93 | 5.32 | 0.39 | 5.94 | 7.04 | 1.10 | Maff (v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)) |
271377 | 7.42 | 7.30 | −0.13 | 7.42 | 8.49 | 1.07 | Zbtb11 (zinc finger and BTB domain containing 11) |
81703 | 4.59 | 4.59 | 0.00 | 5.07 | 6.11 | 1.04 | Jdp2 (Jun dimerization protein 2) |
D. Repressed in hepatocytes, heat shock 43°C | |||||||
21412 | nl | nl | - | 5.82 | 4.75 | −1.08 | Tcf21 (transcription factor 21 |