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Table 4 Selected transcriptional regulators differentially expressed after hyperthermia

From: Impact of heat shock transcription factor 1 on global gene expression profiles in cells which induce either cytoprotective or pro-apoptotic response following hyperthermia

Entrez gene ID Mean SC_C Mean SC_38 SLR SC_38 vs C Mean HEP_C Mean HEP_43 SLR HEP_43 vs C Gene symbol (full name)
A. Induced in spermatocytes, heat shock 38°C
224694 4.30nl 5.82 1.52 nl nl - Zfp81 (zinc finger protein 81)
16600 8.78 10.28 1.49 5.18 5.67 0.49 Klf4 (Kruppel-like factor 4 (gut)
22768 4.37 5.62 1.26 nl nl - Zfy2 (zinc finger protein 2, Y linked)
73503 9.13 10.34 1.21 4.91 5.16 0.25 Mbd3l1 (methyl-CpG binding domain protein 3-like 1)
208727 5.29 6.49 1.19 4.55 4.65 0.09 Hdac4 (histone deacetylase 4)
54427 6.77 7.95 1.19 5.62 5.10 −0.52 Dnmt3l (DNA (cytosine-5-)-methyltransferase 3-like)
12224 8.22 9.39 1.17 4.91 4.64 −0.27 Klf5 (Kruppel-like factor 5)
56381 7.18 8.30 1.12 6.15 6.04 −0.11 Spen (SPEN homolog, transcriptional regulator (Drosophila))
75753 6.08 7.15 1.07 5.12 5.42 0.30 Klf17 (Kruppel-like factor 17)
16870 6.10 7.16 1.06 4.96 4.92 −0.04 Lhx2 (LIM homeobox protein 2)
16601 7.21 8.27 1.06 8.39 8.31 −0.08 Klf9 (Kruppel-like factor 9)
18132 5.99 7.04 1.05 nl nl - Notch4 (Notch gene homolog 4 (Drosophila))
56706 8.61 9.62 1.01 8.57 9.17 0.60 Ccnl1(cyclin L1)
B. Repressed in spermatocytes, heat shock 38°C
60406 9.25 6.78 −2.47 6.10 6.20 0.10 Sap30 (sin3 associated polypeptide)
74197 8.42 6.14 −2.28 6.83 7.04 0.21 Gtf2e1 (general transcription factor II E, polypeptide 1 (alpha subunit))
209707 7.30 5.26 −2.04 4.54 4.85 0.31 Lcorl (ligand dependent nuclear receptor corepressor-like)
15904 8.88 6.88 −2.00 4.79 4.84 0.05 Id4 (inhibitor of DNA binding 4)
71041 9.77 7.93 −1.83 6.81 7.13 0.32 Pcgf6 (polycomb group ring finger 6)
26919 8.66 6.89 −1.77 6.16 6.55 0.40 Zfp346 (zinc finger protein 346)
319944 6.84 5.12 −1.73 5.53 5.44 −0.09 Taf2 (TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor)
22702 6.88 5.22 −1.66 nl nl - Zfp42 (zinc finger protein 428)
231329 8.77 7.34 −1.43 9.50 9.33 −0.17 Polr2b (polymerase (RNA) II (DNA directed) polypeptide B)
102334 7.95 6.48 −1.47 5.90 6.18 0.28 Ankrd10 (ankyrin repeat domain 10)
78912 6.92 5.55 −1.38 5.94 5.88 −0.06 Sp2 (Sp2 transcription factor)
19009 7.02 5.69 −1.33 4.81 4.79 −0.01 Pou6f1 (POU domain, class 6, transcription factor 1)
20687 4.86 3.58 −1.29 7.14 7.07 −0.08 Sp3 (trans-acting transcription factor 3)
75507 9.42 8.19 −1.22 8.05 7.90 −0.15 Pou5f2 (POU domain class 5, transcription factor 2)
100683 7.50 6.29 −1.21 6.94 6.84 −0.10 Trrap (transformation/transcription domain-associated protein)
22632 8.75 7.60 −1.15 9.01 9.33 0.32 Yy1 (YY1 transcription factor)
16476 5.86 4.75 −1.11 8.41 12.47 4.07 Jun (Jun oncogene)
14581 5.65 4.54 −1.11 nl nl - Gfi1(growth factor independent 1)
23894 7.29 6.20 −1.09 6.27 6.25 −0.02 Gtf2h2 (general transcription factor II H, polypeptide 2)
C. Induced in hepatocytes, heat shock 43°C
11910 6.38 5.87 −0.51 6.44 10.80 4.36 Atf3 (activating transcription factor 3)
16476 5.86 4.75 −1.11 8.41 12.47 4.07 Jun (Jun oncogene)
23849 nl nl - 4.63 7.55 2.92 Klf6 (Kruppel-like factor 6)
14281 7.52 6.81 −0.71 9.38 11.94 2.56 Fos (FBJ osteosarcoma oncogene)
13653 7.50 7.65 0.15 10.66 13.03 2.38 Egr1 (early growth response 1)
215418 7.41 7.10 −0.31 7.23 9.28 2.05 Csrnp1 (cysteine-serine-rich nuclear protein 1)
80859 5.12 4.92 −0.20 6.08 7.91 1.83 Nfkbiz (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta)
18030 nl nl - 6.28 7.99 1.71 Nfil3 (nuclear factor, interleukin 3, regulated)
15370 9.23 9.66 0.43 8.51 10.21 1.69 Nr4a1 (nuclear receptor subfamily 4, group A, member 1)
16477 5.86 5.44 −0.42 8.31 9.90 1.59 Junb (Jun-B oncogene)
12053 4.86 5.17 0.31 5.74 7.05 1.31 Bcl6 (B-cell leukemia/lymphoma 6)
15982 6.92 7.31 0.40 7.22 8.41 1.20 Ifrd1 (interferon-related developmental regulator 1)
12192 6.09 7.03 0.94 10.05 11.26 1.21 Zfp36l1 (zinc finger protein 36, C3H type-like 1)
13654 nl nl - 4.09nl 5.28 1.19 Egr2 (early growth response 2)
17133 4.93 5.32 0.39 5.94 7.04 1.10 Maff (v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian))
271377 7.42 7.30 −0.13 7.42 8.49 1.07 Zbtb11 (zinc finger and BTB domain containing 11)
81703 4.59 4.59 0.00 5.07 6.11 1.04 Jdp2 (Jun dimerization protein 2)
D. Repressed in hepatocytes, heat shock 43°C
21412 nl nl - 5.82 4.75 −1.08 Tcf21 (transcription factor 21
  1. The level of expression in spermatocytes (SC) and hepatocytes (HEP) is given in arbitrary units in logarithmic scale (log2). Changes in gene expression (at 38°C or 43°C) are shown as SLRs.
  2. nl noise level.