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Table 5 The most significant changes in expression of genes involved in the inflammatory and immune responses

From: Impact of heat shock transcription factor 1 on global gene expression profiles in cells which induce either cytoprotective or pro-apoptotic response following hyperthermia

Entrez gene ID Mean SC_C Mean SC_38 SLR SC_38 vs C Mean HEP_C Mean HEP_43 SLR HEP_43 vs C Gene symbol (full name)
16071 4.07nl 5.30 1.23 7.09 7.49 0.40 Igkc (immunoglobulin kappa constant)
11450 7.57 8.78 1.21 4.85 4.90 0.05 Adipoq (adiponectin, C1Q and collagen domain containing)
142687 5.02 6.12 1.10 nl nl - Asb14 (ankyrin repeat and SOCS box-containing 14)
58185 5.42 6.49 1.07 5.89 5.78 −0.11 Rsad2 (radical S-adenosyl methionine domain containing 2)
71785 4.36nl 5.38 1.02 nl nl - Pdgfd (platelet-derived growth factor, D polypeptide)
217845 5.03 6.04 1.02 4.78 4.89 0.11 Ifi27l2b (interferon, alpha-inducible protein 27 like 2B)
57444 8.56 9.57 1.01 5.36 5.19 −0.17 Isg20 (interferon-stimulated protein)
54131 8.33 7.20 −1.13 8.51 8.53 0.02 Irf3 (interferon regulatory factor 3)
67781 7.26 6.25 −1.02 5.93 5.80 −0.13 Ilf2 (interleukin enhancer binding factor 2)
12702 5.36 5.32 −0.04 6.55 9.88 3.32 Socs3 (suppressor of cytokine signaling 3)
20310 5.48 5.75 0.27 4.57 6.64 2.06 Cxcl2 (chemokine (C-X-C motif) ligand 2)
12475 6.19 6.17 −0.02 7.20 9.03 1.82 Cd14 (CD14 antigen)
12522 4.52 4.50 −0.02 4.76 6.50 1.73 Cd83 (CD83 antigen)
20210 6.92 6.83 −0.10 7.97 9.56 1.59 Saa3 (serum amyloid A 3)
14825 6.13 6.49 0.36 8.53 10.11 1.57 Cxcl1 (chemokine (C-X-C motif) ligand 1)
21824 4.68 4.70 0.02 5.12 6.64 1.52 Thbd (thrombomodulin)
211770 5.29 5.63 0.35 6.47 7.99 1.52 Trib1 (tribbles homolog 1 (Drosophila))
16175 5.18 5.62 0.44 6.26 7.55 1.28 Il1a (interleukin 1 alpha)
11504 4.60 4.82 0.22 5.71 6.80 1.09 Adamts1 (a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1)
278180 4.49nl 4.62 0.13 9.28 7.69 −1.59 Vsig4 (V-set and immunoglobulin domain containing 4)
110454 6.40 6.74 0.34 9.50 8.36 −1.14 Ly6a (lymphocyte antigen 6 complex, locus A)
  1. The level of expression in spermatocytes (SC) and hepatocytes (HEP) is given in arbitrary units in logarithmic scale (log2). Changes in gene expression after hyperthermia (at 38°C or 43°C) are shown as SLRs.
  2. nl noise level.
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BMC Genomics

ISSN: 1471-2164

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