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Table 8 Top HSF1-bound genes induced or repressed in spermatocytes and hepatocytes following heat shock

From: Impact of heat shock transcription factor 1 on global gene expression profiles in cells which induce either cytoprotective or pro-apoptotic response following hyperthermia

Gene symbol

Mean expression

SLR

Mean expression

SLR HEP_43 vs C

HSF1 binding (AB1-AB0)

 

SC_C

SC_38

SC_43

SC_38 vs C

SC_43 vs C

HEP_C

HEP_43

 

SC_38

SC_43

HEP_43

A. Induced in spermatocytes, heat shock 38°C

Spen

7.18

8.30

7.06

1.12

−0.12

6.35

6.04

−0.31

14.05

50.30

12.89*

Asb14

5.02

6.12

5.05

1.10

0.03

nl

nl

-

24.00

20.80

-

Adam21

8.02

9.05

8.01

1.03

−0.01

5.65

5.98

0.34

21.03

17.76*

-

1700109H08Rik

9.46

10.41

9.42

0.95

−0.04

4.71

4.85

0.14

28.80

49.60

35.0

B. Repressed in spermatocytes, heat shock 38°C

6330503K22Rik

10.09

7.93

10.11

−2.16

0.03

5.09

5.65

0.56

65.99

82.04

27.33

Topbp1

8.01

6.44

7.47

−1.57

−0.54

5.68

5.80

0.11

122.90

96.50

160.08*

Fam178a

7.88

6.36

7.65

−1.52

−0.23

7.13

7.48

0.35

67.15

76.91

66.54

Specc1l

8.78

7.47

8.57

−1.31

−0.22

7.38

7.30

−0.08

82.75

113.69

46.78

Cdc42

7.79

6.51

7.29

−1.29

−0.50

10.04

9.84

−0.20

38.25

35.53

28.38

Rbm27

7.33

6.09

7.26

−1.24

−0.07

7.08

7.11

0.03

42.30

54.71

31.60

Trrap

7.50

6.29

7.18

−1.21

−0.32

6.94

6.84

−0.10

54.75

78.92

85.63

Piwil2

9.36

8.16

9.14

−1.20

−0.22

4.57

4.53

−0.04

58.29

69.75

-

Prpf4b

7.43

6.32

7.39

−1.11

−0.04

7.32

7.57

0.25

63.92

60.88

47.68

Dock7

8.23

7.13

7.95

−1.10

−0.29

6.73

6.74

0.01

53.87

80.68

58.32

Mov10l1

8.54

7.47

8.22

−1.07

−0.32

5.80

6.03

0.23

60.84

94.50

-

BC026590

7.64

6.60

7.21

−1.04

−0.42

5.08

5.19

0.11

40.27

40.98

51.39

Srp68

9.74

8.72

9.61

−1.01

−0.12

8.89

8.93

0.04

38.09

61.12

43.79

C. Induced in hepatocytes, heat shock 43°C

Hsph1

7.77

7.64

7.84

−0.13

0.07

9.18

11.65

2.47

22.13

72.09

102.11

Zfand2a

6.57

6.20

6.56

−0.37

−0.01

6.43

8.44

2.01

10.50

46.06

60.47

Phlda1

nl

nl

nl

-

-

11.41

12.95

1.54

16.38

15.60

47.09

Mpp4

4.57

4.55

4.80

−0.02

0.24

4.89

6.04

1.15

28.00

51.81

47.75

Hsp90ab1

9.94

9.35

9.89

−0.59

−0.05

11.29

12.31

1.02

51.71

120.95

99.84

Slc10a2

nl

nl

nl

-

-

4.08nl

5.10

1.02

-

-

54.11

Hspe1

7.03

7.09

6.91

0.06

−0.12

8.63

9.64

1.01

31.92

78.72

81.14

Prdm15

5.05

4.94

4.83

−0.11

−0.23

4.70

5.49

0.79

27.64

47.05

42.34

Rbbp6

6.53

6.23

6.49

−0.30

−0.04

5.76

6.51

0.75

51.16

61.71

93.60

D. Repressed in hepatocytes, heat shock 43°C

Cyp4a10

nl

nl

nl

-

-

8,25#

4,63

−3,62

-

-

31,90

Sdc4

5.96

5.94

5.92

−0.03

−0.05

11.47#

9.90#

−1.57

-

-

25.93

Pabpc2

12.54

12.23

12.30

−0.31

−0.24

5.42

4.67

−0.75

-

19.81*

17.61

  1. *FDR > 0.125; nl noise level, #high standard deviation (in a range 1.1 – 3.6).