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Table 8 Top HSF1-bound genes induced or repressed in spermatocytes and hepatocytes following heat shock

From: Impact of heat shock transcription factor 1 on global gene expression profiles in cells which induce either cytoprotective or pro-apoptotic response following hyperthermia

Gene symbol Mean expression SLR Mean expression SLR HEP_43 vs C HSF1 binding (AB1-AB0)
  SC_C SC_38 SC_43 SC_38 vs C SC_43 vs C HEP_C HEP_43   SC_38 SC_43 HEP_43
A. Induced in spermatocytes, heat shock 38°C
Spen 7.18 8.30 7.06 1.12 −0.12 6.35 6.04 −0.31 14.05 50.30 12.89*
Asb14 5.02 6.12 5.05 1.10 0.03 nl nl - 24.00 20.80 -
Adam21 8.02 9.05 8.01 1.03 −0.01 5.65 5.98 0.34 21.03 17.76* -
1700109H08Rik 9.46 10.41 9.42 0.95 −0.04 4.71 4.85 0.14 28.80 49.60 35.0
B. Repressed in spermatocytes, heat shock 38°C
6330503K22Rik 10.09 7.93 10.11 −2.16 0.03 5.09 5.65 0.56 65.99 82.04 27.33
Topbp1 8.01 6.44 7.47 −1.57 −0.54 5.68 5.80 0.11 122.90 96.50 160.08*
Fam178a 7.88 6.36 7.65 −1.52 −0.23 7.13 7.48 0.35 67.15 76.91 66.54
Specc1l 8.78 7.47 8.57 −1.31 −0.22 7.38 7.30 −0.08 82.75 113.69 46.78
Cdc42 7.79 6.51 7.29 −1.29 −0.50 10.04 9.84 −0.20 38.25 35.53 28.38
Rbm27 7.33 6.09 7.26 −1.24 −0.07 7.08 7.11 0.03 42.30 54.71 31.60
Trrap 7.50 6.29 7.18 −1.21 −0.32 6.94 6.84 −0.10 54.75 78.92 85.63
Piwil2 9.36 8.16 9.14 −1.20 −0.22 4.57 4.53 −0.04 58.29 69.75 -
Prpf4b 7.43 6.32 7.39 −1.11 −0.04 7.32 7.57 0.25 63.92 60.88 47.68
Dock7 8.23 7.13 7.95 −1.10 −0.29 6.73 6.74 0.01 53.87 80.68 58.32
Mov10l1 8.54 7.47 8.22 −1.07 −0.32 5.80 6.03 0.23 60.84 94.50 -
BC026590 7.64 6.60 7.21 −1.04 −0.42 5.08 5.19 0.11 40.27 40.98 51.39
Srp68 9.74 8.72 9.61 −1.01 −0.12 8.89 8.93 0.04 38.09 61.12 43.79
C. Induced in hepatocytes, heat shock 43°C
Hsph1 7.77 7.64 7.84 −0.13 0.07 9.18 11.65 2.47 22.13 72.09 102.11
Zfand2a 6.57 6.20 6.56 −0.37 −0.01 6.43 8.44 2.01 10.50 46.06 60.47
Phlda1 nl nl nl - - 11.41 12.95 1.54 16.38 15.60 47.09
Mpp4 4.57 4.55 4.80 −0.02 0.24 4.89 6.04 1.15 28.00 51.81 47.75
Hsp90ab1 9.94 9.35 9.89 −0.59 −0.05 11.29 12.31 1.02 51.71 120.95 99.84
Slc10a2 nl nl nl - - 4.08nl 5.10 1.02 - - 54.11
Hspe1 7.03 7.09 6.91 0.06 −0.12 8.63 9.64 1.01 31.92 78.72 81.14
Prdm15 5.05 4.94 4.83 −0.11 −0.23 4.70 5.49 0.79 27.64 47.05 42.34
Rbbp6 6.53 6.23 6.49 −0.30 −0.04 5.76 6.51 0.75 51.16 61.71 93.60
D. Repressed in hepatocytes, heat shock 43°C
Cyp4a10 nl nl nl - - 8,25# 4,63 −3,62 - - 31,90
Sdc4 5.96 5.94 5.92 −0.03 −0.05 11.47# 9.90# −1.57 - - 25.93
Pabpc2 12.54 12.23 12.30 −0.31 −0.24 5.42 4.67 −0.75 - 19.81* 17.61
  1. *FDR > 0.125; nl noise level, #high standard deviation (in a range 1.1 – 3.6).
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BMC Genomics

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