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Table 9 Characteristics of genes necessary for spermatogenesis whose repression following heat shock in spermatocytes correlates with HSF1 binding

From: Impact of heat shock transcription factor 1 on global gene expression profiles in cells which induce either cytoprotective or pro-apoptotic response following hyperthermia

Gene symbol (full name) Changes in expression (SLR) HSF1 binding (AB1-AB0) Function
  SC_38 vs C SC_43 vs C HEP_43 vs C SC_38 SC_43 HEP_43  
Dnaja1 (DnaJ (Hsp40) homolog, subfamily A, member 1) −1.09 −0.07 1.17 34.4 69.9 40.5 Cochaperone of HSP70s in protein folding and mitochondrial protein import. Its loss in mice led to severe defects in spermatogenesis [31].
Celf1 (CUGBP, Elav-like family member 1) −1.07 −0.01 0.19 35.1 48.3 24.5 Post-transcriptional regulation: pre-mRNA alternative splicing, mRNA translation and stability. Required for completion of spermatogenesis [32].
Spo11 (sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae)) −1.19 0.07 −0.03 33.0 53.3 - A type II like topoisomerase; required for meiotic recombination [33, 34].
Piwil2 (piwi-like homolog 2 (Drosophila)) −1.20 −0.22 −0.04 58.3 69.8 - Participates in the repression of transposable elements in spermatogenic cells; involved in translation regulation [35, 36].
Tdrd1 (tudor domain containing 1) −1.57 −0.40 0.42 23.8 48.1 - Participates in the repression of transposable elements in spermatogenic cells [37].
Mov10l1 (Moloney leukemia virus 10-like 1, homolog (mouse)) −1.07 −0.32 0.23 60.8 94.5 - Putative RNA helicase, essential for silencing retrotransposons in the mouse male germline [38, 39].