Global Rsh-dependent transcription profile of Brucella suisduring stringent response unravels adaptation to nutrient starvation and cross-talk with other stress responses

Table 1 Genes identified as being positively regulated by Rsh during stringent response, and previously described as essential for virulence of Brucella spp. in in vitro and/or in vivo models of infection

B. suisGene ID	B. melitensisGene ID	Gene	Putative or assessed function	References
BR0511	BMEI1426	wbpL	O-chain biosynthesis	[35, 42]
BR0615	BMEI1326	lpsA	Putative glycosyltransferase	[35, 42]
BR0915	BMEI1056	amiC	Cell-wall hydrolysis	[42]
BR0982	BMEI0997	wbdA	O-chain biosynthesis	[35, 42]
BR1930	BMEI0135	omp19	Lipoprotein	[42]
BRA0703	BMEII0581	sodC	Cu/Zn super oxide dismutase	[42, 52]
BR2183	BMEI1946	mutM	Repair from mutagenesis by alkylating agents	[42]
BRA0599	BMEII0670	pyrB	Pyrimidines biosynthesis	[42]
BR0363, BR0360	BMEI1564, BMEI1566	ccoN, P	cytochrome c oxidase, cbb3-type	[26, 27]
BR0569	BMEI1364	mucR	Transcriptional regulator	[35]
BR1514	BMEI0498	csp	Cold shock protein	[35]
BRA0065	BMEII0029	virB5	Macromolecule secretion	[42]
BRA1012	BMEI0433	dppA	Dipeptide uptake	[42]
BR0049	BMEI1894	-	Conserved hypothetical protein	[35]

ISSN: 1471-2164