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Table 4 Bioinformatic analysis to identify the existence of potential regulations in the C1R-mediated cluster through pathway enrichment analysis

From: Systems infection biology: a compartmentalized immune network of pig spleen challenged with Haemophilus parasuis

Pathway names

Enriched genes in pathway

P value

Adjust P value

1. Pathway Commons database

   

Inflammatory Response Pathway

IL4R, THBS1

4.42e-05

0.0001

Focal Adhesion

ITGA5, SPP1, THBS1

2.93e-05

0.0001

TGF Beta Signaling Pathway

SPP1, THBS1

0.0001

0.0002

Senescence and Autophagy

CEBPB, THBS1

0.0002

0.0003

Adipogenesis

CEBPB, CEBPD

0.0009

0.0009

Initial triggering of complement

C1R, CFB

6.60e-05

0.0006

Complement cascade

C1R, CFB

6.60e-05

0.0006

Syndecan-4-mediated signaling events

ITGA5, THBS1

0.0003

0.0019

IL6-mediated signaling events

CEBPB, CEBPD

0.0003

0.0019

Exocytosis of Alpha granule

ITGA5, THBS1

0.0003

0.0019

Platelet degranulation

ITGA5, THBS1

0.0004

0.0024

IL4-mediated signaling events

CEBPB, IL4R

0.0005

0.0026

Response to elevated platelet cytosolic Ca++

ITGA5, THBS1

0.0005

0.0026

Innate Immunity Signaling

C1R, CFB

0.0007

0.0030

Platelet Activation

ITGA5, THBS1

0.0008

0.0033

Regulation of p38-alpha and p38-beta

CEBPB, PTPN1

0.0028

0.0104

Proteogylcan syndecan-mediated signaling events

ITGA5, THBS1

0.0035

0.0124

p38 MAPK signaling pathway

CEBPB, PTPN1

0.0037

0.0125

Plasma membrane estrogen receptor signaling

CEBPB, PTPN1

0.0048

0.0150

BMP receptor signaling

CEBPB, PTPN1

0.0053

0.0159

Regulation of nuclear SMAD2/3 signaling

CEBPB, PTPN1

0.0101

0.0246

TGF-beta receptor signaling

CEBPB, PTPN1

0.0101

0.0246

Regulation of cytoplasmic and nuclear SMAD2/3 signaling

CEBPB, PTPN1

0.0101

0.0246

Glypican 1 network

CEBPB, PTPN1

0.0224

0.0380

Glypican pathway

CEBPB, PTPN1

0.0258

0.0386

2. Wikipathways database

   

Inflammatory Response Pathway

IL4R, THBS1

4.42e-05

0.0001

Focal Adhesion

ITGA5, SPP1, THBS1

2.93e-05

0.0001

TGF Beta Signaling Pathway

SPP1, THBS1

0.0001

0.0002

Senescence and Autophagy

CEBPB, THBS1

0.0002

0.0003

Adipogenesis

CEBPB, CEBPD

0.0009

0.0009

3. KEGG database

   

ECM-receptor interaction

ITGA5, SPP1, THBS1

2.75e-06

1.65e-05

Focal adhesion

ITGA5, SPP1, THBS1

3.76e-05

0.0001

Cytokine-cytokine receptor interaction

IL4R, CXCL2, IL10RB

8.72e-05

0.0002

Complement and coagulation cascades

C1R, CFB

0.0002

0.0003

Hematopoietic cell lineage

ITGA5, IL4R

0.0004

0.0005

Jak-STAT signaling pathway

IL4R, IL10RB

0.0012

0.0012