Skip to main content
Figure 6 | BMC Genomics

Figure 6

From: Coexpression analysis of large cancer datasets provides insight into the cellular phenotypes of the tumour microenvironment

Figure 6

Conservation of transcriptional signatures in graph derived from skin cancer dataset (Pearson correlation threshold r = 0.80). In order to provide a clear view of transcripts/clusters within skin cancer graph it has been simplified. The network shown here has been constructed with a central framework of edges derived from the relationships between clusters and nodes representing the transcripts in each cluster joined to a central node representing the cluster with the graph laid out in 2D. Only clusters comprising more than 8 probesets were included. a) Colours represent different clusters in the skin cancer data, and b) overlay of clusters from the merged cancer (r = 0.6) graph displayed using larger nodes. Many of the housekeeping clusters (1–5, 11) can be seen to be conserved, as is a proportion of the cell cycle (6), macrophage (7), T-cell (8), ECM (9), interferon response (12), plasma cell (14), MHC class 1 (19), histones (20) and Affymetrix control (23) clusters. However it can also be seen that many of the skin cancer clusters are not represented in the merged cancer profile set, these transcriptional signatures being unique to skin cancers.

Back to article page