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Table 1 List of the significantly deregulated miRNAs in plexiform neurofibromas relative to dermal neurofibromas

From: MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis

miRNAs Functionally verified gene target(s) Location Host gene Dermal neurofibromas (n = 9) Plexiform neurofibromas (n = 41) Fold changea P b Peripheral nerves (n = 2)c
Significantly upregulated miRNAs in plexiform neurofibromas relative to dermal neurofibromas  
miR-486-3p PTEN[10] 8p11.2 ANK1 1.3 [0.03-12.8]d 9.3 [0.02-198.0] 7.41 0.002 1.4 [0.90-1.8]
miR-185   22q11.2   2.8 [0.10-23.6] 16.0 [0.04-97.5] 5.67 0.003 8.4 [3.1-13.8]
miR-362-5p   Xp11.2 CLCN5 4.8 [0.09-72.6] 18.5 [0.03-312.0] 3.90 0.008 21.3 [7.2-35.4]
miR-370 MAP3K8[11] 14q32.2   13.8 [5.4-33.0] 28.7 [0.08-232.6] 2.08 0.008 11.5 [10.8-12.1]
miR-491-5p   9p21.3   12.8 [2.0-22.1] 22.6 [0.02-115.3] 1.76 0.014 27.6 [23.8-31.3]
miR-143 KRAS[12] 5q32   185.0 [68.1-411.0] 437.7 [3.3-3156.7] 2.37 0.016 426.1 [339.9-512.4]
miR-193a-5p   17q11.2   2.0 [0.58-13.5] 16.9 [0.02-168.9] 8.57 0.017 11.3 [8,0-14.5]
miR-483-5p   11p15.5 IGF2 7.4 [0.27-24.2] 19.7 [0.02-326.9] 2.67 0.020 112.3 [38.7-185.8]
miR-181a KRAS[13] and ATM[14] 1q32.1 and 9q33.3 NR6A1 (9q33.3) 8.2 [0.71-84.3] 36.3 [0.02-231.0] 4.44 0.022 10.7 [5.7-15.7]
miR-145 RREB1[15] 5q32   436.3 [259.8-2572.9] 1792.9 [22.9-14808.8] 4.11 0.024 830.3 [688.1-972.4]
Significantly down-regulated miRNA in plexiform neurofibromas relative to dermal neurofibromas  
miR-203   14q32.3   36.2 [1.2-10966.7] 4.8 [0.05-2943.7] 0.13 0.010 2.6 [2.3-2.8]
  1. aMedian expression in plexiform neurofibromas/Median expression in dermal neurofibromas.
  2. bMann-Whitney’s U Test.
  3. cNon tumorigenic controls.
  4. dMedian [range] of miRNAs levels.