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Table 5 The rate of synonymous (Ks) and non-synonymous (Ka) nucleotide substitution for secretory (signal peptide and mature peptide) and non-secretory proteomes

From: Contrasted evolutionary constraints on secreted and non-secreted proteomes of selected Actinobacteria

  Ka (±S. E.) Ks (±S. E.) Ka/Ks (±S. E.)
Frankia ACN/ CcI    
Signal Peptide (SP) 0.897 ± 0.335 11.698 ± 2. 627 0.182 ± 0.031
Mature Peptide (MP) 0.151 ± 0.009 10.499 ± 3. 11 0.066 ± 0.005
Secretory Protein (Sec) 0.105 ± 0.006 6.893 ± 2. 006 0.051 ± 0.003
Non-secretory Protein (NSec) 0.083 ± 0.002 6.555 ± 0.614 0.043 ± 0.001
Frankia ACN/ FD    
Signal Peptide (SP) 0.5656 ± 0.2004 24.4256 ± 14.1669 0.1952 ± 0.063
Mature Peptide (MP) 0.2370 ± 0.0328 12.1243 ± 9.3627 0.0980 ± 0.028
Secretory Protein (Sec) 0.2690 ± 0.0255 27.415 ± 10.51547 0.077 ± 0.0211
Non-secretory Protein (NSec) 0.1862 ± 0.0028 31.77567 ± 1.283 0.0336 ± 0.001
Frankia ACN/ Ean    
Signal Peptide (SP) 2.14 ± 0.6975 23.82 ± 4. 32 0.479 ± 0.262
Mature Peptide (MP) 0.194 ± 0.0124 29.85 ± 6. 224 0.0363 ± 0.005
Secretory Protein (Sec) 0.183 ± 0.008 29.785 ± 4. 460 0.040 ± 0.004
Non-secretory Protein (NSec) 0.144 ± 0.002 23.688 ± 1. 120 0.036 ± 0.001
Frankia ACN/ Eul    
Signal Peptide (SP) 2. 99 ± 0.754 29. 198 ± 4. 055 0.568 ± 0.211
Mature Peptide (MP) 0.258 ± 0.011 50.244 ± 6. 94 0.035 ± 0.004
Secretory Protein (Sec) 0.235 ± 0.008 36. 971 ± 4. 836 0.043 ±0.004
Non-secretory Protein (NSec) 0.178 ± 0.003 33. 228 ± 1. 306 0.035 ± 0.001
Frankia CcI/FD    
Signal Peptide (SP) 0.3762 ± 0.0565 5.4064 ± 2.5889 0.2136 ± 0.0524
Mature Peptide (MP) 0.2367 ± 0.0208 19.3491 ± 9.5834 0.0581 ± 0.0104
Secretory Protein (Sec) 0.265 ± 0.02113 18.01 ± 7.5958 0.0633 ± 0.0103
Non-secretory Protein (NSec) 0.1901 ± 0.003 28.1726 ± 1.158 0.0334 ± 0.001
Frankia CcI/ Ean    
Signal Peptide (SP) 0.451 ± 0.125 12.861 ± 6.345 0.139 ± 0.054
Mature Peptide (MP) 0.206 ± 0.015 23.179 ± 10.192 0.043 ± 0.008
Secretory Protein (Sec) 0.179 ± 0.010 35.333 ± 4. 793 0.027 ± 0.003
Non-secretory Protein (NSec) 0.147 ± 0.002 24.320 ± 1. 059 0.031 ± 0.001
Frankia CcI/ Eu1    
Signal Peptide (SP) 2.202 ± 1. 866 13.475 ± 8. 425 0.282 ± 0.111
Mature Peptide (MP) 0.143 ± 0.025 21.280 ± 9. 465 0.070 ± 0.014
Secretory Protein (Sec) 0.097 ± 0.006 5.761 ± 2. 462 0.061 ± 0.005
Non-secretory Protein (NSec) 0.097 ± 0.015 5.244 ± 0.511 0.047 ± 0.001
Frankia FD/ Eu1    
Signal Peptide (SP) 0.450 ± 0.125 12.86 ± 6.34 0.138 ± 0.053
Mature Peptide (MP) 0.205 ± 0.015 23.179 ± 10.19 0.0429 ± 0.008
Secretory Protein (Sec) 0.307 ± 0.015 30.9 ± 10.99 0.0502 ± 0.0125
Non-secretory Protein (NSec) 0.189 ± 0.002 25.7 ± 1.32 0.0288 ± 0.009
Frankia FD/ Ean    
Signal Peptide (SP) 2.202 ± 1.865 13.475 ± 8.4 0.282 ± 0.11
Mature Peptide (MP) 0.143 ± 0.022 21.28 ± 5.96 0.070 ± 0.011
Secretory Protein (Sec) 0.329 ± 0.016 29.094 ±10.111 0.053 ± 0.011
Non-secretory Protein (NSec) 0.203 ± .002 23.128 ± 8.98 0.028 ± .009
Frankia Ean/ Eul    
Signal Peptide (SP) 0.677 ± 0.037 20.845 ± 8. 942 0.321 ± 0.034
Mature Peptide (MP) 0.235 ± 0.021 23.780 ± 7. 688 0.065 ± 0.005
Secretory Protein (Sec) 0.230 ± 0.009 51.172 ± 5. 025 0.033 ± 0.001
Non-secretory Protein (NSec) 0.201 ± 0.013 32.649 ± 1. 250 0.032 ± 0.004
S. coelicolor/S. avermitilis    
Signal Peptide (SP) 0.483 ± 0.157 10.529 ± 2. 48 0.166 ±0.016
Mature Peptide (MP) 0.144 ± 0.005 11.029 ± 3. 42 0.061 ± 0.003
Secretory Protein (Sec) 0.142 ± 0.005 13.460 ± 3. 072 0.066 ± 0.003
Non-secretory Protein (NSec) 0.109 ± 0.002 10.344 ± 0.601 0.052 ± 0.001
S. coelicolor/S. griseus    
Signal Peptide (SP) 0.952 ± 0.229 26.889 ± 3.260 0.157 ± 0.0250
Mature Peptide (MP) 0.210 ± 0.007 28.96 ± 5.938 0.049 ±0.003
Secretory Protein (Sec) 0.226 ± 0.007 39.273 ± 4.598 0.048 ± 0.004
Non-secretory Protein (NSec) 0.166 ± 0.002 27.224 ± 0.941 0.043 ± 0.001
S. coelicolor- S. somaliensis    
Signal Peptide (SP) 1.648 ± 0.439 26.224 ± 5.183 0.324 ± 0.113
Mature Peptide (MP) 0.227 ± 0.009 35.567 ± 3.675 0.033 ± 0.005
Secretory Protein (Sec) 0.235 ± 0.005 45.582 ± 7.275 0.041 ± 0.005
Non-secretory Protein (NSec) 0.151 ± 0.002 26.060 ± 1.209 0.040 ± 0.001
S. coelicolor- S. scabiei    
Signal Peptide (SP) 0.585 ± 0.126 15.974 ± 2.126 0.177 ± 0.016
Mature Peptide (MP) 0.172 ± 0.005 18.214 ± 3.100 0.057 ± 0.003
Secretory Protein (Sec) 0.159 ± 0.008 15.480 ± 4.913 0.067 ± 0.005
Non-secretory Protein (NSec) 0.103 ± 0.002 10.699 ± 0.802 0.050 ± 0.001
S. avermitilis- S. somaliensis    
Signal Peptide (SP) 0.634 ± 0.101 23.098 ± 4.180 0.347 ± 0.088
Mature Peptide (MP) 0.233 ± 0.009 43.112 ± 6.251 0.040 ± 0.005
Secretory Protein (Sec) 0.236 ± 0.008 41.932 ± 6.196 0.042 ± 0.005
Non-secretory Protein (NSec) 0.147 ± 0.002 27.533 ± 1.286 0.036 ± 0.001
S. avermitilis- S. scabiei    
Signal Peptide (SP) 0.554 ± 0.146 12.172 ± 1.912 0.268 ± 0.038
Mature Peptide (MP) 0.164 ± 0.005 13.605 ± 2.619 0.068 ± 0.003
Secretory Protein (Sec) 0.134 ± 0.006 3.663 ± 1.879 0.084 ± 0.005
Non-secretory Protein (NSec) 0.096 ± 0.002 7.412 ± 0.719 0.055 ± 0.001
S. avermitilis/ S. griseus    
Signal Peptide (SP) 1.359 ± 0.326 21.298 ± 2.755 0.504 ± 0.036
Mature Peptide (MP) 0.210 ± 0.007 48.403 ± 6.312 0.037 ± 0.003
Secretory Protein (Sec) 0.234 ± 0.006 44. 581 ± 4.500 0.047 ± 0.005
Non-secretory Protein (NSec) 0.158 ± 0.002 26. 284 ± 0.889 0.040 ± 0.001
S. somaliensis- S. scabiei    
Signal Peptide (SP) 1.346 ± 0.450 25.264 ± 4.391 0.492 ± 0.283
Mature Peptide (MP) 0.223 ± 0.007 24.696 ± 5.321 0.032 ± 0.004
Secretory Protein (Sec) 0.232 ± 0.008 42.124 ± 6.385 0.056 ± 0.006
Non-secretory Protein (NSec) 0.151 ± 0.002 27.537 ± 1.294 0.035 ± 0.004
S. somaliensis- S. griseus    
Signal Peptide (SP) 0.565 ± 0.145 20.919 ± 3.434 0.170 ± 0.026
Mature Peptide (MP) 0.220 ± 0.009 42.007 ± 6.413 0.034 ± 0.004
Secretory Protein (Sec) 0.197 ± 0.006 38.510 ± 6.153 0.043 ± 0.005
Non-secretory Protein (NSec) 0.157 ± 0.039 20.710 ± 3.643 0.041 ± 0.003
S. scabiei- S. griseus    
Signal Peptide (SP) 0.734 ± 0.178 22.970 ± 2.788 0.743 ± 0.256
Mature Peptide (MP) 0.216 ± 0.007 49.319 ± 6.226 0.037 ± 0.003
Secretory Protein (Sec) 0.211 ± 0.008 36.526 ± 6.828 0.046 ± 0.005
Non-secretory Protein (NSec) 0.148 ± 0.002 24.148 ± 1.233 0.040 ± 0.001
M. tuberculosis/M. leprae    
Signal Peptide (SP) 0.414 ± 0.0408 12.978 ± 6.284 0.165 ± 0.069
Mature Peptide (MP) 0.111 ± 0.011 1.406 ± 0.055 0.079 ± 0.008
Secretory Protein (Sec) 0.137 ± 0.009 1.4109 ± 0.076 0.099 ± 0.008
Non-secretory Protein (NSec) 0.122 ± 0.002 2.173 ± 0.288 0.088 ± 0.001
M. tuberculosis/M. smegmatis    
Signal Peptide (SP) 1.059 ± 0.273 30.888 ± 8.194 0.098 ± 0.031
Mature Peptide (MP) 0.199 ± 0.021 23.071 ± 10.099 0.043 ± 0.014
Secretory Protein (Sec) 0.239 ± 0.017 39.868 ± 9.856 0.032 ± 0.0105
Non-secretory Protein (NSec) 0.163 ± 0.003 28.329 ± 1.413 0.030 ± 0.001
M. tuberculosis/ M. ulcerans    
Signal Peptide (SP) 0.685 ± 0.258 8.146 ± 3.966 0.436 ± 0.159
Mature Peptide (MP) 0.109 ± 0.014 5.997 ± 4.625 0.069 ± 0.010
Secretory Protein (Sec) 0.127 ± 0.012 1.48434 ± 0.077 0.0864 ± 0.007
Non-secretory Protein (NSec) 0.096 ± 0.002 2.616 ± 0.353 0.065 ± 0.001
M. tuberculosis/ M. vanbaalenii    
Signal Peptide (SP) 0.821 ± 0.083 13.294 ± 5.633 0.247 ± 0.072
Mature Peptide (MP) 0.226 ± 0.018 21.208 ± 9.415 0.053 ± 0.012
Secretory Protein (Sec) 0.247 ± 0.015 20.711 ± 7.419 0.049 ± 0.009
Non-secretory Protein (NSec) 0.168 ± 0.003 26.060 ± 1.344 0.032 ± 0.001
M. leprae/ M. smegmatis    
Signal Peptide (SP) 1.003 ± 0.129 20.464 ± 6.323 0.207 ± 0.062
Mature Peptide (MP) 0.247 ± 0.025 16.558 ± 5.325 0.0278 ± 0.005
Secretory Protein (Sec) 0.281 ± 0.018 34.78545 ± 6.822 0.02763 ± 0.006
Non-secretory Protein (NSec) 0.188 ± 0.003 28.210 ± 1.291 0.026 ± 0.001
M. leprae/ M. ulcerans    
Signal Peptide (SP) 0.462 ± 0.056 14.975 ± 6.791 0.273 ± 0.080
Mature Peptide (MP) 0.158 ± 0.021 6.794 ± 4.753 0.0731 ± 0.009
Secretory Protein (Sec) 0.176 ± 0.020 5.359 ± 3.338 0.081 ± 0.007
Non-secretory Protein (NSec) 0.132 ± 0.003 2.877 ± 0.312 0.070 ± 0.002
M. leprae/ M. vanbalanii    
Signal Peptide (SP) 1.322 ± 0.349 33.707 ± 8.948 0.115 ± 0.048
Mature Peptide (MP) 0.278 ± 0.0267 17.136 ± 6.912 0.038 ± 0.006
Secretory Protein (Sec) 0.302 ± 0.021 25.442 ± 6.775 0.041 ± 0.008
Non-secretory Protein (NSec) 0.193 ± 0.004 25.629 ± 1.238 0.029 ± 0.001
M. smegmatis / M. ulcerans    
Signal Peptide (SP) 1.409 ± 0.415 18.212 ± 5.189 0.293 ± 0.138
Mature Peptide (MP) 0.225 ± 0.0184 18.889 ± 7.0584 0.041947 ± 0.007
Secretory Protein (Sec) 0.257 ± 0.017 27.432 ± 6.438 0.037 ± 0.006
Non-secretory Protein (NSec) 0.163 ± 0.003 28.286 ± 1.443 0.030008 ± 0.001
M. smegmatis / M. vanbaalenii    
Signal Peptide (SP) 3.458 ± 1.548 19.415 ± 5.519 0.668 ± 0.356
Mature Peptide (MP) 0.1737 ± 0.014936 19.717 ± 8.35107 0.0518 ± 0.0084
Secretory Protein (Sec) 0.2046 ± 0.01668 23.418 ± 7.994028 0.0621 ± 0.0111
Non-secretory Protein (NSec) 0.1252 ± 0.0027 16.09933 ± 1.215 0.0416 ± 0.0014
M. ulcerans / M. vanbaalenii    
Signal Peptide (SP) 1.640 ± 0.833 20.487 ± 5.451 0.1985 ± 0.0625
Mature Peptide (MP) 0.2575 ± 0.017255 13.6171 ± 4.540 0.0524 ± 0.0084
Secretory Protein (Sec) 0.2721 ± 0.0158 24.692 ± 6.523 0.0438 ± 0.0071
Non-secretory Protein (NSec) 0.165 ± 0.0031 27.909 ± 1.427 0.0309 ± 0.0011