Figure 1

Types of protein-level functional implications of interrogated AS events. The AS events detected in both whole blood and leukocyte exon array data sets of PD patients and healthy control (HC) volunteers, and pre- and post- DBS treatment, included alternative N and C termini, retained introns, alternative coding of internal gene regions, NMD and truncation (>50% reduction in protein product size). Top: a schematic structure of a gene. Grey: introns, color coded regions: exons. Direction: from 5’ to 3’ UTR. PTC: Pre-Termination codon. Below it, the structure of a full transcript is given, with a theoretical protein product structure.