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Figure 4 | BMC Genomics

Figure 4

From: Distinct roles of the Gcn5 histone acetyltransferase revealed during transient stress-induced reprogramming of the genome

Figure 4

Gene expression patterns during stress adaptation and recovery are not correlated with gene-length. A Dendrogram showing the extent of overall RNA abundance level differences in samples collected during the stress and recovery growth regime. The 854 genes that show a change of at least 1.8-fold in at least one of samples B, C, D, and E in relation to sample A were included in the analysis. B Genes regulated during the stress and recovery growth regime can be grouped into clusters showing three main patterns of gene expression. Heat maps showing fold change values for genes in samples A-E in relation to their starting level (sample A), for each of the three k-means clusters identified from the 854 regulated genes identified in part A. Log2 transformed fold change values are represented by colors in the heat map and the color range of the heat map is shown by the scale bar. The average expression level values for each sample and cluster are shown in the lower panels and the number of genes in each cluster is shown in parenthesis. C Scatter plot showing the lack of any discernable correlation between gene regulation changes (stress adaptation sample B vs normal conditions sample A) and gene length. Log2 transformed fold change values are plotted against Log2 transformed gene length values. Spearman’s rank correlation coefficient rs= 0.0095 (p=0.4739). D Box plot shows difference in gene length distributions for the 3 clusters of regulated genes. The distribution of gene length (log2) for the 3 clusters of genes is shown. The median value is shown by black line.

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