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Figure 7 | BMC Genomics

Figure 7

From: Distinct roles of the Gcn5 histone acetyltransferase revealed during transient stress-induced reprogramming of the genome

Figure 7

The level of transient gene activation during stress adaptation is significantly correlated with the extent of the transient increase in H3K18ac and Gcn5 on corresponding promoters. A Significant correlation between the extent of gene regulation during stress adaptation and levels of increased H3K18ac as well as between gene activation and Gcn5 levels that occur at the same time. The bar charts show the Spearman’s rank correlation coefficients (rs) for the levels of gene regulation during stress adaptation in relation to the levels of changes in H3K18ac, H4K16ac and Gcn5 (left panel) as well as for levels of up-and down-regulation during the same period in relation to the levels of changes in Gcn5 (right panel). Statistically supported correlation coefficients (*) as well as coefficients lacking statistical support (ns) are indicated. The p-values for comparison of regulation level with H3K18ac, H4K16ac and Gcn5 levels were 2.20E-16, 0.32 and 0.64 and for comparison between the levels of up- and down regulation with Gcn5 levels they were 4.81E-4 and 0.71, respectively. B Significant correlation between transcript abundance and levels of H3K18ac, H4K16ac and Gcn5. Annotations are as for part A. The p-values for comparison of transcript abundance with H3K18ac, H4K16ac and Gcn5 are 2.20E-16, 1.73E-05 and 2.20E-16, respectively. C No significant correlation between gene regulation level during stress adaptation and transcript abundance. Scatter plot showing Log2 transformed fold change values for the stress adaptation period plotted against Log2 transcript abundance values. The Spearman rank correlation coefficient is 0.004 (p=0.77).

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