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Table 2 Common core set of DE genes modulated by L-OHP in the tested cell lines

From: Oxaliplatin induces different cellular and molecular chemoresistance patterns in colorectal cancer cell lines of identical origins

Gene symbol

Gene name

Colo 320R

HT-29R

Fold regulation

p value

Fold regulation

p value

Class A

TMX4

Thioredoxin-related transmembrane protein 4

3.43

1.18E-06

2.73

6.57E-10

PTPRO

Protein tyrosine phosphatase, receptor type, O

1.58

2.58E-05

1.85

1.93E-08

LGALS1

Lectin, galactoside-binding, soluble, 12

2.71

7.32E-07

1.58

3.62E-09

KRT18

Keratin 18, transcript variant 1

1.87

7.29E-08

1.54

1.81E-07

THC2739159

ALU8_HUMAN (P39195) Alu subfamily SX sequence contamination warning entry, partial (8%)

2.04

2.48E-04

1.77

7.46E-08

XR_019191

PREDICTED: Homo sapiens similar to Keratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18) (K18) (LOC121054), mRNA [XR_019191]

2.00

7.97E-09

1.56

6.13E-08

XR_017030

Heat-shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27) (Stress responsive protein 27) (SRP27) (Estrogen-regulated 24 kDa protein) (28 kDa heat shock protein)

1.99

1.30E-08

1.53

8.82E-08

XR_018843

PREDICTED: Homo sapiens similar to Keratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18) (K18) (LOC649233), mRNA [XR_018843

1.93

8.66E-07

1.71

1.52E-05

AK022045

Homo sapiens cDNA FLJ11983 fis, clone HEMBB1001337

1.80

1.24E-05

1.82

6.51E-09

THC2611661

RR12_SPIMX (P42344) Chloroplast 30S ribosomal protein S12, partial (11%)

1.80

2.24E-04

1.51

8.50E-08

THC2524582

Q5U0N8_HUMAN (Q5U0N8) Keratin 18 (Cell proliferation-inducing protein 46), partial (46%) [THC2524582]

1.75

3.60E-07

1.57

8.96E-07

NM_173624

KRT18P55 keratin 18 pseudogene 55

1.72

3.34E-07

1.57

1.13E-06

XR_018670

PREDICTED: Homo sapiens similar to Keratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18) (K18) (LOC643471), mRNA [XR_018670]

1.72

1.71E-07

1.51

6.88E-08

XR_015605

PREDICTED: similar to Keratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18) (K18) (LOC731794), mRNA

1.71

3.34E-07

1.51

4.97E-07

BC048264

Homo sapiens hypothetical protein LOC283666, mRNA (cDNA clone IMAGE:4415549), partial cds

1.71

3.63E-05

1.88

1.27E-08

XR_018311

PREDICTED: Homo sapiens similar to Keratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18) (K18) (LOC139060), mRNA [XR_018311]

1.67

2.29E-05

1.55

1.23E-07

NM_001007139

Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 2, mRNA

2.08

7.10E-06

1.53

6.85E-09

THC2663167

ALU1_HUMAN (P39188) Alu subfamily J sequence contamination warning entry, partial (5%) [THC2663167]

2.07

3.24E-04

1.55

1.17E-08

Class B

IL1RAP

Interleukin 1 receptor accessory protein

-1.61

2.86E-05

-1.53

4.67E-07

GRB14

Growth factor receptor-bound protein 14

-1.73

3.97E-07

-1.56

4.16E-09

RBPMS2

RNA binding protein with multiple splicing 2

-1.60

1.19E-04

-1.58

8.16E-07

RHOBTB1

Rho-related BTB domain containing 1

-1.58

7.77E-05

-1.67

3.44E-07

CD302

CD302 molecule

-1.88

2.57E-06

-1.68

1.07E-09

HMGCS1

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

-1.56

2.38E-04

-1.73

2.77E-07

POLR1D

Polymerase (RNA) I polypeptide D, 16 kDa

-1.52

1.44E-06

-1.74

3.02E-10

CA12

Carbonic anhydrase XII (CA12), transcript variant 1

-2.60

2.55E-10

-1.95

4.95E-11

AKR1B1

Aldo-keto reductase family 1, member B10

-1.91

1.78E-07

-3.18

2.54E-12

Class C

IFITM3

Interferon induced transmembrane protein 3

-1.74

1.87E-07

2.08

1.28E-11

IFITM4P

Interferon induced transmembrane protein 4 pseudogene

-1.60

3.88E-07

1.78

1.28E-08

IFIH1

Interferon induced with helicase C domain 1

-2.64

1.40E-07

1.67

4.51E-08

CFHR1

Complement factor H-related 1

-2.64

4.32E-09

1.61

1.70E-08

Class D

CAMK2N1

Calcium/calmodulin-dependent protein kinase II inhibitor 1

1.64

1.33E-07

-1.55

3.97E-07

SAMD5

Sterile alpha motif domain containing 5

1.51

2.41E-04

-1.73

8.09E-09

NDRG1

N-myc downstream regulated 1

1.79

7.96E-07

-1.75

1.55E-07

COL9A3

Collagen, type IX, alpha 3

1.91

3.92E-06

-1.79

6.45E-09

IRX5

Iroquois homeobox 5

1.88

1.94E-07

-1.53

9.56E-08

  1. Classes A and B represent up- respectively down-regulated genes induced by L-OHP in Colo320R and HT-29R. Classes C and D include antagonist DE genes induced by L-OHP in the tested cell lines.
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BMC Genomics

ISSN: 1471-2164

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