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Table 2 Common core set of DE genes modulated by L-OHP in the tested cell lines

From: Oxaliplatin induces different cellular and molecular chemoresistance patterns in colorectal cancer cell lines of identical origins

Gene symbol Gene name Colo 320R HT-29R
Fold regulation p value Fold regulation p value
Class A
TMX4 Thioredoxin-related transmembrane protein 4 3.43 1.18E-06 2.73 6.57E-10
PTPRO Protein tyrosine phosphatase, receptor type, O 1.58 2.58E-05 1.85 1.93E-08
LGALS1 Lectin, galactoside-binding, soluble, 12 2.71 7.32E-07 1.58 3.62E-09
KRT18 Keratin 18, transcript variant 1 1.87 7.29E-08 1.54 1.81E-07
THC2739159 ALU8_HUMAN (P39195) Alu subfamily SX sequence contamination warning entry, partial (8%) 2.04 2.48E-04 1.77 7.46E-08
XR_019191 PREDICTED: Homo sapiens similar to Keratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18) (K18) (LOC121054), mRNA [XR_019191] 2.00 7.97E-09 1.56 6.13E-08
XR_017030 Heat-shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27) (Stress responsive protein 27) (SRP27) (Estrogen-regulated 24 kDa protein) (28 kDa heat shock protein) 1.99 1.30E-08 1.53 8.82E-08
XR_018843 PREDICTED: Homo sapiens similar to Keratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18) (K18) (LOC649233), mRNA [XR_018843 1.93 8.66E-07 1.71 1.52E-05
AK022045 Homo sapiens cDNA FLJ11983 fis, clone HEMBB1001337 1.80 1.24E-05 1.82 6.51E-09
THC2611661 RR12_SPIMX (P42344) Chloroplast 30S ribosomal protein S12, partial (11%) 1.80 2.24E-04 1.51 8.50E-08
THC2524582 Q5U0N8_HUMAN (Q5U0N8) Keratin 18 (Cell proliferation-inducing protein 46), partial (46%) [THC2524582] 1.75 3.60E-07 1.57 8.96E-07
NM_173624 KRT18P55 keratin 18 pseudogene 55 1.72 3.34E-07 1.57 1.13E-06
XR_018670 PREDICTED: Homo sapiens similar to Keratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18) (K18) (LOC643471), mRNA [XR_018670] 1.72 1.71E-07 1.51 6.88E-08
XR_015605 PREDICTED: similar to Keratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18) (K18) (LOC731794), mRNA 1.71 3.34E-07 1.51 4.97E-07
BC048264 Homo sapiens hypothetical protein LOC283666, mRNA (cDNA clone IMAGE:4415549), partial cds 1.71 3.63E-05 1.88 1.27E-08
XR_018311 PREDICTED: Homo sapiens similar to Keratin, type I cytoskeletal 18 (Cytokeratin-18) (CK-18) (Keratin-18) (K18) (LOC139060), mRNA [XR_018311] 1.67 2.29E-05 1.55 1.23E-07
NM_001007139 Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 2, mRNA 2.08 7.10E-06 1.53 6.85E-09
THC2663167 ALU1_HUMAN (P39188) Alu subfamily J sequence contamination warning entry, partial (5%) [THC2663167] 2.07 3.24E-04 1.55 1.17E-08
Class B
IL1RAP Interleukin 1 receptor accessory protein -1.61 2.86E-05 -1.53 4.67E-07
GRB14 Growth factor receptor-bound protein 14 -1.73 3.97E-07 -1.56 4.16E-09
RBPMS2 RNA binding protein with multiple splicing 2 -1.60 1.19E-04 -1.58 8.16E-07
RHOBTB1 Rho-related BTB domain containing 1 -1.58 7.77E-05 -1.67 3.44E-07
CD302 CD302 molecule -1.88 2.57E-06 -1.68 1.07E-09
HMGCS1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 -1.56 2.38E-04 -1.73 2.77E-07
POLR1D Polymerase (RNA) I polypeptide D, 16 kDa -1.52 1.44E-06 -1.74 3.02E-10
CA12 Carbonic anhydrase XII (CA12), transcript variant 1 -2.60 2.55E-10 -1.95 4.95E-11
AKR1B1 Aldo-keto reductase family 1, member B10 -1.91 1.78E-07 -3.18 2.54E-12
Class C
IFITM3 Interferon induced transmembrane protein 3 -1.74 1.87E-07 2.08 1.28E-11
IFITM4P Interferon induced transmembrane protein 4 pseudogene -1.60 3.88E-07 1.78 1.28E-08
IFIH1 Interferon induced with helicase C domain 1 -2.64 1.40E-07 1.67 4.51E-08
CFHR1 Complement factor H-related 1 -2.64 4.32E-09 1.61 1.70E-08
Class D
CAMK2N1 Calcium/calmodulin-dependent protein kinase II inhibitor 1 1.64 1.33E-07 -1.55 3.97E-07
SAMD5 Sterile alpha motif domain containing 5 1.51 2.41E-04 -1.73 8.09E-09
NDRG1 N-myc downstream regulated 1 1.79 7.96E-07 -1.75 1.55E-07
COL9A3 Collagen, type IX, alpha 3 1.91 3.92E-06 -1.79 6.45E-09
IRX5 Iroquois homeobox 5 1.88 1.94E-07 -1.53 9.56E-08
  1. Classes A and B represent up- respectively down-regulated genes induced by L-OHP in Colo320R and HT-29R. Classes C and D include antagonist DE genes induced by L-OHP in the tested cell lines.