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Table 3 Top canonical pathways modulated by L-OHP in Colo320R

From: Oxaliplatin induces different cellular and molecular chemoresistance patterns in colorectal cancer cell lines of identical origins

Canonical pathways Colo320R

p-value

Log Ratio

Molecules

Aryl hydrocarbon receptor signaling

1E-03

5.59E-02

HSPB3, CDKN2A, MYC, FOS, GSTM2, ALDH1A1, NQO1, TGFB2, HSPB1

HGF Signaling

3E-03

6.67E-02

CDKN2A, MET, FOS, MAP3K6, MAP3K13, ETS2, ELK3

LPS/IL-1 mediated inhibition of RXR function

7E-03

4.18E-02

CHST2, ABCB1, GSTM2, ALDH1A1, SLC27A2, HS3ST1, CPT1C, PLTP, HMGCS1, IL1RAP

Hepatic fibrosis/hepatic stellate cell activation

1.6E-02

4.79E-02

MET, TIMP1, ACTA2, TGFB2, IGFBP5, IL1RAP, COL3A1

Retinoate biosynthesis I

1.8E-02

7.89E-02

ALDH1A1, RBP7, AKR1C3

Methylglyoxal degradation III

1.68E-02

8.7E-02

AKR1C3, AKR1B1

S-methyl-5′-thioadenosine degradation II

1.9E-02

1.67E-01

MTAP

Histamine biosynthesis

1.9E-02

3.33E-01

HDC

Retinol biosynthesis

2.5E-02

4.92E-02

DHRS3, RBP7, LPL

Cell Cycle: G1/S checkpoint regulation

2.7E-02

6.06E-02

CDKN2A, MYC, HDAC9, TGFB2

The visual cycle

2.9E-02

7.14E-02

DHRS3, RBP7

PXR/RXR activation

3.2E-02

4.6E-02

ABCB1, GSTM2, ALDH1A1, FOXO1

Glutamine biosynthesis I

3.8E-02

1.25E-01

GLUL

Thyroid cancer signaling

4.2E-02

7.14E-02

PPARG, MYC, NTF3

Mitochondrial L-carnitine shuttle pathway

4.2E-02

9.09E-02

SLC27A2, CPT1C