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Table 3 Top canonical pathways modulated by L-OHP in Colo320R

From: Oxaliplatin induces different cellular and molecular chemoresistance patterns in colorectal cancer cell lines of identical origins

Canonical pathways Colo320R p-value Log Ratio Molecules
Aryl hydrocarbon receptor signaling 1E-03 5.59E-02 HSPB3, CDKN2A, MYC, FOS, GSTM2, ALDH1A1, NQO1, TGFB2, HSPB1
HGF Signaling 3E-03 6.67E-02 CDKN2A, MET, FOS, MAP3K6, MAP3K13, ETS2, ELK3
LPS/IL-1 mediated inhibition of RXR function 7E-03 4.18E-02 CHST2, ABCB1, GSTM2, ALDH1A1, SLC27A2, HS3ST1, CPT1C, PLTP, HMGCS1, IL1RAP
Hepatic fibrosis/hepatic stellate cell activation 1.6E-02 4.79E-02 MET, TIMP1, ACTA2, TGFB2, IGFBP5, IL1RAP, COL3A1
Retinoate biosynthesis I 1.8E-02 7.89E-02 ALDH1A1, RBP7, AKR1C3
Methylglyoxal degradation III 1.68E-02 8.7E-02 AKR1C3, AKR1B1
S-methyl-5′-thioadenosine degradation II 1.9E-02 1.67E-01 MTAP
Histamine biosynthesis 1.9E-02 3.33E-01 HDC
Retinol biosynthesis 2.5E-02 4.92E-02 DHRS3, RBP7, LPL
Cell Cycle: G1/S checkpoint regulation 2.7E-02 6.06E-02 CDKN2A, MYC, HDAC9, TGFB2
The visual cycle 2.9E-02 7.14E-02 DHRS3, RBP7
PXR/RXR activation 3.2E-02 4.6E-02 ABCB1, GSTM2, ALDH1A1, FOXO1
Glutamine biosynthesis I 3.8E-02 1.25E-01 GLUL
Thyroid cancer signaling 4.2E-02 7.14E-02 PPARG, MYC, NTF3
Mitochondrial L-carnitine shuttle pathway 4.2E-02 9.09E-02 SLC27A2, CPT1C