Genomic characterization provides new insight into Salmonella phage diversity

Table 2 Antimicrobial resistance, virulence and DNA metabolism genes identified in phages sequenced in this study

Function	Gene	Phages harboring this gene
Resistance	Tellurite resistance, TerB	Cluster 3
	Bicyclomycin resistance protein	FSL SP-016
Virulence	Agglutinating adhesin	Cluster 3
	Virulence protein MsgA/putative damage inducible protein DinI¹	FSL SP-016
DNA metabolism	Thymidylate synthase	Clusters 2, 3, 4
	Ribonucleotide reductase of class III, large subunit	Clusters 2, 3, 4
	Ribonucleotide reductase of class III, activating subunit	Clusters 2, 3, 4
	Glutaredoxin	Clusters 2, 4
	Deoxyuridine 5′-triphosphate nucleotidohydrolase	Clusters 3, 6
	Dihydrofolate reductase	Cluster 4
	Ribose-phosphate pyrophosphokinase	Cluster 4
	Ribonucleotide reductase of class Ia, alpha subunit	Cluster 4
	Ribonucleotide reductase of class Ia, beta subunit	Cluster 4
	Exodeoxyribonuclease	Cluster 4
	Ribose phosphate pyrophosphokinase	Cluster 4
	Nicotinamide phosphoribosyltransferase	Cluster 4
	Deoxynucleotide monophosphate kinase	Cluster 4
	Ribonuclease HI	Cluster 2
	dCMP deaminase	Cluster 2
	Nucleoside 2-deoxyribosyltransferase	Cluster 1

¹ This protein shows homology with both DinI ((pfam06183 [1.35e-08]) and with MsgA, (97% of aa identity with Gifsy-2 prophage MsgA). Experimental data will be needed to assign a functionally appropriate name to this gene.