Figure 1

The Gal4BD-Spo11 allele is insufficient to maintain normal fertility. H&E-stained histological sections are shown. “Gal” indicates the Gal4BD-Spo11 allele, “+” indicates the wild type allele and “–”indicates the null allele of the Spo11 gene. A. Testes. Note the abundance of spermatocytes, but lack of spermatids in the seminiferous tubules of Spo11^Gal/Gal mice. B. Epididymus. Note the lack of spermatozoa in the Spo11^Gal/Gal mice. C. Ovaries. A few follicles are evident in the Spo11^Gal/Gal 3 month old females, but none in the Spo11^Gal/- mice.