The relationship between effective population size ( Ne ) and the MAF of polymorphisms in the regions surrounding the most conserved genes. For genes with the highest GERP scores (top 10%), the average MAF scores surrounding genes in each population, with population codes shown in the corresponding colour to the right of each line (A). The correlation between Ne and the depth of depression in MAF around the most highly conserved genes for old world populations that we have Ne data (B). Population codes are as follows: Utah residents with Northern and Western European ancestry (CEU), British in England and Scotland (GBR), Toscani in Italy (TSI), Finnish from Finland (FIN), Han Chinese in Beong, China (CHB), Southern Han Chinese (CHS), Japanese in Tokyo, Japan (JPN), Yoruba in Idadan, Nigeria (YRI), Luhya in Webuye, Kenya (LWK), Americans of African Ancestry in S.W. USA (ASW), Mexican ancestry from Los Angeles, USA (MXL), Puerto Ricans from Puerto Rico (PUR) and Colombians from Medellin, Colombia (CLM).