Figure 9

Gene network of known relationships among those differentially expressed genes that were extracellular signaling factors, growth factors, growth factor binding proteins, growth factor receptors or hormone receptors (see Additional file 2 : Table S1: categories ‘Growth Factors’ and ‘Receptors & Binding Proteins’). Node shapes code: oval – protein; diamond – ligand; circle/oval on tripod platform – transcription factor/hormone receptor; ice cream cone – receptor. Grey arrows represent regulation, lilac – expression, green – promoter binding, olive – protein modification, purple - binding. Plasma membrane and cell nucleus are indicated for gene expression localization.