Skip to main content

Table 1 Classification accuracy after establishing a cut-off percentage of risky combinatory genotypes in each gene cluster

From: Construction of gene clusters resembling genetic causal mechanisms for common complex disease with an application to young-onset hypertension

Datasets Population Classification accuracy S1(S2) Sensitivity S1(S2) Specificity S1(S2) Subjects with risky genotypes
      HT NC
FHS_Affy500k (training) Caucasian 99.7%+(99.1%) 0.99(0.98) 1.0(0.996) 87 239
Taiwan_Affy500k (training) Taiwanese 98.2%+(93.4%) 0.97(0.97) 1.0(0.89) 97 70
WTCCC_Affy500k (test) Caucasian 61.6%(62.9%) 0.25(0.26) 0.85(0.87) 214 336
Taiwan_Affy100k & Taiwan_Illu550k (test) Taiwanese 98.2%(98.2%) 0.97(0.94) 1.0(1.0) 138* 89*
Overall Both 82.8%(82.5%) 0.68(0.69) 0.93(0.93) 536 734
Overall except WTCCC_Affy500k Both 98.9%(97.5%) 0.98(0.97) 1.0(0.98) 322 398
  1. S1: threshold is computed for each dataset; S2: threshold is computed for each platform; +Classification accuracy of the dataset evaluated using a five-fold validation procedure exhibit similar result and is presented in Additional file 1: Table S5; *see Additional file 1: Figure S1 for detailed calculations.