The relationship between survival time of patients with breast cancer and inferred E2F4 activity score. The Vijv dataset is used in the calculation. (a) Two breast cancer samples with an E2F4 regulatory score of -41.5 and 5.95, respectively. (b) Distribution of E2F4 activity scores in the 260 samples. (c) The survival curves of patients with breast cancer. “E2F4>0” shows patients with positive E2F4 activity scores; “E2F4<0” shows patients with negative E2F4 activity scores. (d) The survival curves of four categories patients: ER+ & E2F4>0, ER+ & E2F4<0, ER- & E2F4>0 and ER- & E2F4<0. E2F4 activity score is inferred based on the Sydh_Helas3_E2F4 binding profile.