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Table 1 Top 10 TF binding profiles with significantly different activities between ER+ and ER- breast cancer samples in the Veer and the Wang datasets

From: REACTIN: Regulatory activity inference of transcription factors underlying human diseases with application to breast cancer

The Veer data  
Cell line TF Condition Lab RAS Location P-value FDR
T47d Eralphaa Gen1h Haib 6.424 0.174 0 0.005
T47d Eralphaa Estradia1h Haib 6.424 0.174 0 0.011
T47d Foxa1 Dmso2 Haib 5.427 0.174 0 0.036
T47d Gata3 Dmso2 Haib 5.263 0.174 0 0.039
T47d P300 Dmso2 Haib 4.372 0.180 0.002 0.266
Hepg2 Foxa1   Haib 3.905 0.158 0.001 0.413
T47d Eralphaa Dmso2 Haib 3.946 0.247 0.012 0.438
Ecc1 Eralphaa Estradia1h Haib 4.006 0.126 0 0.457
Mcf7 Cmyc Estro Broad 1.710 0.637 0.206 0.695
H1hesc Ctcf   Broad 1.710 0.106 0.184 0.701
The Wang data  
Cell line TF Condition Lab RAS Location P-value FDR
T47d Eralphaa Gen1h Haib 6.538 0.135 0 0.003
T47d Eralphaa Estradia1h Haib 6.538 0.135 0 0.007
T47d Gata3 Dmso2 Haib 4.874 0.189 0.006 0.142
T47d Foxa1 Dmso2 Haib 5.076 0.189 0.003 0.142
Ecc1 Eralphaa Estradia1h Haib 4.953 0.094 0 0.146
Ecc1 Eralphaa Gen1h Haib 3.929 0.126 0.005 0.872
Hl60 Ctcf   Uw -1.042 0.704 0.365 0.901
H1hesc Sin3ak20   Haib 0.735 0.233 0.454 0.921
Gm19239 Ctcf   Broad -0.917 0.035 0.417 0.801
A549 Gr Dexd Haib 0.725 0.281 0.444 0.924
  1. The “Location” column shows the percentile of genes at which the maximum deviation is observed. TF binding profiles with a FDR<0.25 are highlighted in bold.