REACTIN: Regulatory activity inference of transcription factors underlying human diseases with application to breast cancer

Table 2 TF binding profiles with significantly different activities between breast tumor and normal breast tissues

Tumor (38) versus normal (28): FDR <0.05
TF	Cell line	Condition	Lab	RAS	Location	P-value
Stat1	K562	Ifnah6h	Sydh	6.252	0.164	0
Stat2	K562	Ifnah6h	Sydh	6.274	0.164	0
Stat1	K562	Ifnah30	Sydh	5.674	0.159	0
Stat2	K562	Ifnah30	Sydh	5.287	0.157	0
Tumor stoma (20) versus normal stroma (14): FDR<0.05
TF	Cell line	Condition	Lab	RAS	Location	P-value
Baf155	Helas3		Sydh	5.095	0.260	0
Gr	A549	Dexc	Haib	5.119	0.225	0.004
Ini1	Helas3		Sydh	4.973	0.252	0.003
Gr	A549	Dexc	Haib	5.125	0.249	0.003
Znf274	Helas3		Sydh	5.207	0.326	0.01
Fosl1	K562		Haib	4.888	0.298	0.003
Pu1	K562		Haib	5.221	0.298	0
Tumor epithelium (18) versus normal epithelium (14) top 20
TF	Cell line	Condition	Lab	RAS	Location	P-value
E2f4	Helas3		Sydh	6.151	0.178	0
Stat1	K562	Ifna30	Sydh	5.726	0.235	0
E2f4	K562b		Sydh	5.158	0.165	0
Stat2	K562	Ifna30	Sydh	5.788	0.239	0
Stat1	K562	Ifna6h	Sydh	5.857	0.239	0
Stat2	K562	Ifna6h	Sydh	5.469	0.238	0
E2f1	Helas3		Sydh	5.290	0.167	0
Eralphaa	T47d	Dmso2	Haib	5.042	0.236	0
Irf3	Helas3		Sydh	4.947	0.235	0
E2f1	Mcf7		Sydh	4.962	0.166	0
Stat1	Helas3	Ifng30	Sydh	4.831	0.205	0
Eralphaa	T47d	Gen1h	Haib	4.726	0.167	0.002
Stat1	K562	Ifng6h	Sydh	4.781	0.236	0.002
Nyfb	K562		Sydh	4.751	0.116	0
Baf170	Helas3		Sydh	4.688	0.195	0.004
Eralphaa	T47d	Estradia1h	Haib	4.726	0.167	0.002
Nyfa	K562		Sydh	4.627	0.214	0.
Sta1	K562	Ifng30	Sydh	4.635	0.236	0.001
Sp1	K562		Haib	4.547	0.214	0.001

ISSN: 1471-2164