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Table 2 TF binding profiles with significantly different activities between breast tumor and normal breast tissues

From: REACTIN: Regulatory activity inference of transcription factors underlying human diseases with application to breast cancer

Tumor (38) versus normal (28): FDR <0.05
TF Cell line Condition Lab RAS Location P-value
Stat1 K562 Ifnah6h Sydh 6.252 0.164 0
Stat2 K562 Ifnah6h Sydh 6.274 0.164 0
Stat1 K562 Ifnah30 Sydh 5.674 0.159 0
Stat2 K562 Ifnah30 Sydh 5.287 0.157 0
Tumor stoma (20) versus normal stroma (14): FDR<0.05
TF Cell line Condition Lab RAS Location P-value
Baf155 Helas3   Sydh 5.095 0.260 0
Gr A549 Dexc Haib 5.119 0.225 0.004
Ini1 Helas3   Sydh 4.973 0.252 0.003
Gr A549 Dexc Haib 5.125 0.249 0.003
Znf274 Helas3   Sydh 5.207 0.326 0.01
Fosl1 K562   Haib 4.888 0.298 0.003
Pu1 K562   Haib 5.221 0.298 0
Tumor epithelium (18) versus normal epithelium (14) top 20
TF Cell line Condition Lab RAS Location P-value
E2f4 Helas3   Sydh 6.151 0.178 0
Stat1 K562 Ifna30 Sydh 5.726 0.235 0
E2f4 K562b   Sydh 5.158 0.165 0
Stat2 K562 Ifna30 Sydh 5.788 0.239 0
Stat1 K562 Ifna6h Sydh 5.857 0.239 0
Stat2 K562 Ifna6h Sydh 5.469 0.238 0
E2f1 Helas3   Sydh 5.290 0.167 0
Eralphaa T47d Dmso2 Haib 5.042 0.236 0
Irf3 Helas3   Sydh 4.947 0.235 0
E2f1 Mcf7   Sydh 4.962 0.166 0
Stat1 Helas3 Ifng30 Sydh 4.831 0.205 0
Eralphaa T47d Gen1h Haib 4.726 0.167 0.002
Stat1 K562 Ifng6h Sydh 4.781 0.236 0.002
Nyfb K562   Sydh 4.751 0.116 0
Baf170 Helas3   Sydh 4.688 0.195 0.004
Eralphaa T47d Estradia1h Haib 4.726 0.167 0.002
Nyfa K562   Sydh 4.627 0.214 0.
Sta1 K562 Ifng30 Sydh 4.635 0.236 0.001
Sp1 K562   Haib 4.547 0.214 0.001