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Table 3 TF binding profiles that are significantly correlated with survival of patients with breast cancer (the Vijv dataset)

From: REACTIN: Regulatory activity inference of transcription factors underlying human diseases with application to breast cancer

Lab_Cell line_TF_Condition P-value Adjusted P value Hazard ratio 95% CI P-value Adjusted P value Hazard ratio 95% CI
Sydh_helas3_E2f6 5.96E-06 0.0017 1.073 (1.041, 1.106) 8.44E-05 0.0163 1.064 (1.032, 1.097)
Sydh_K562_Cfos 1.03E-05 0.0017 1.114 (1.062, 1.168) 0.0001 0.0163 1.099 (1.047, 1153)
Sydh_K562_Stat1_Ifng30 1.17E-05 0.0017 1.264 (1.138, 1.403) 0.0002 0.0163 1.221 (1.099, 1.358)
Sydh_K562_Brf2 2046E-05 0.0019 1.172 (1.089, 1.262) 0.0003 0.0163 1.147 (1.065, 1.235)
Sydh_K562_Brf1 2.52E-05 0.0019 1.228 (1.116, 1.350) 0.0003 0.0163 1.192 (1.084, 1.311)
Sydh_K562_Cmyc_Ifng6h 2.62E-05 0.0019 1.322 (1.163, 1.513) 0.0005 0.0168 1.271 (1.111, 1.453)
Sydh_Helas3_Ini1 3.67E-05 0.0020 1.292 (1.144, 1.460) 0.0004 0.0168 1.240 (1.100, 1.396)
Sydh_K562_Tf3c110 3.85E-05 0.0020 1.221 (1.110, 1.343) 0.0003 0.0163 1.193 (1.085, 1.312)
Sydh_K562b_Znf274 4.74E-05 0.0022 1.236 (1.116, 1.369) 0.0006 0.0168 1.198 (1.081, 1.328)
Sydh_K562_Cmyc 5.50E-05 0.0023 1.290 (1.140, 1.461) 0.0006 0.0168 1.242 (1.098, 1.405)
Haib_Gm12878_Atf3 5.84E-05 0.0023 1.230 (1.112, 1.361) 0.0003 0.0163 1.201 (1.088, 1.327)
Sydh_Hepg2_Srebp1 7.36E-05 0.0024 1.211 (1.102, 1.332) 0.0005 0.0168 1.191 (1.080, 1.313)
Sydh_Helas3_E2f4 8.36E-05 0.0024 1.291 (1.137, 1.467) 0.0007 0.0182 1.237 (1.094, 1.400)
Sydh_K562_Cmyc_Ifng30 9.17E-05 0.0024 1.254 (1.120, 1.405) 0.0006 0.0172 1.225 (1.090, 1.376)
Sydh_K562_Cjun_Ifng6h 0.0001 0.0027 1.291 (1.134, 1.469) 0.0014 0.0220 1.233 (1.084, 1.402)
Sydh_K562_Ccnt 0.0001 0.0028 1.345 (1.156, 1.564) 0.0012 0.0220 1.303 (1.110, 1.530)
Sydh_K562b_Gata2 0.0001 0.0028 1.128 (1.061, 1.200) 0.0017 0.0227 1.106 (1.039, 1.178)
Sydh_K562_Irf1_Ifng6h 0.0001 0.0030 1.185 (1.086, 1.293) 0.0009 0.0215 1.159 (1.062, 1.624)
Sydh_K562_Bdp1 0.0002 0.0033 1.233 (1.106, 1.375) 0.0020 0.0246 1.190 (1.066, 1.330)
Sydh_K562_Rpc155 0.0002 0.0035 1.410 (1.177, 1.689) 0.0012 0.0220 1.353 (1.127, 1.624)
Haib_Hepg2_Rxra 0.0002 0.0035 1.210 (1.095, 1.338) 0.0013 0.0220 1.179 (1.067, 1.303)
Sydh_K562_Hmgn3 0.0002 0.0035 1.180 (1.082, 1.288) 0.0156 0.0620 1.122 (1.022, 1.233)
Uw_K562_Ctcf 0.0002 0.0035 1.298 (1.131, 1.490) 0.0013 0.0220 1.268 (1.097, 1.465)
Haib_Hepg2_Fosl2 0.0002 0.0039 1.419 (1.177, 1.711) 0.0015 0.0220 1.360 (1.125, 10645)
Haib_Hepg2_Hdac2 0.0003 0.0040 1.178 (1.079, 1.286) 0.0019 0.0241 1.150 (1.053, 1.255)
Sydh_K562_Brg1 0.0003 0.0040 1.106 (1.048, 1.168) 0.0038 0.0317 1.085 (1.027, 1.358)
Haib_Hepg2_Gabp 0.0003 0.0043 1.238 (1.103, 1.390) 0.0017 0.0227 1.207 (1.074, 1.358)
Sydh_Gm12878_Ctcf 0.0003 0.0045 1.333 (1.140, 1.558) 0.0012 0.0220 1.290 (1.106, 1.504)
Haib_Hepg2_Sp1 0.0003 0.0045 1.153 (1.067, 1.247) 0.0014 0.0220 1.135 (1.050, 1.226)
Haib_Gm12878_Bcl11a 0.0003 0.0045 1.220 (1.094, 1.361) 0.0012 0.0220 1.194 (1.072, 1.329)
Sydh_Mcf7_Hae2f1 0.0004 0.0045 1.224 (1.095, 1.367) 0.0004 0.0168 1.228 (1.096, 1.376)
Sydh_Helas3_Cjun 0.0004 0.0045 1.075 (1.033, 1.118) 0.0028 0.0293 1.063 (1.021, 1.106)
Haib_Hepg2_Sin3ak20 0.0004 0.0045 1.368 (1.151, 1.626) 0.0014 0.0220 1.323 (1.114, 1.571)
Sydh_K562_Stat1_Infa6h 0.0004 0.0045 1.273 (1.114, 1.455) 0.0032 0.0295 1.222 (1.069, 1.397)
Sydh_Ntd1_Znf274 0.0004 0.0049 1.204 (1.086, 1.336) 0.0026 0.0286 1.174 (1.058, 1.303)
  1. The hazard ratio and 95% confidence interval (CI) are calculated using cox proportional hazards model with single variable or multiple variables. In the multiple cox regression model, ESR (Estrogen receptor status) and Posnodes (lymph node status) are included as variables together with the inferred TF activity scores.