Figure 4

GSEA enrichment plots for the five gene sets enriched in EOCs. On the top of each plot, the name of the gene set is reported. For each gene set, the enrichment plot was extracted from the GSEA output results and each gene set showed significant enrichment in IL6 expressing advanced stage EOC (FDR Q value = 0.0; Fig. 3). Genes with higher expression in IL6-positive tumors have higher enrichment scores, and are therefore plotted on the left side of the graph, whereas those with lower expression in IL6-positive tumors have lower enrichment scores and are plotted on the right side of the graph. The bottom portion of the plot shows the value of the ranking metric moving down the list of ranked genes. A positive ranking metric indicates that a gene is correlated with the IL6 positive phenotype. The results from dataset 1 are reported.