Figure 3
From: TGFβ and CCN2/CTGF mediate actin related gene expression by differential E2F1/CREB activation
Altered CREB/E2F1 signalling networks in co-treated HMCs. A. Pathway analysis with Ingenuity IPA software identified interacting partners of CREB differentially expressed in response to treatment with TGFβ. B. In comparison, fewer genes related to CREB signalling were differentially expressed in co-treated cells. C. Similarly, pathway analysis identified E2F1 interacting partners in cells treated with TGFβ. D. The number of E2F1 partners was enriched by co-treatment with TGFβ and CCN2. Interacting partners coloured pink/red were increased in expression in response to treatment, those coloured green were decreased in expression.