Table 2 Low abundance toxin classes

CTL

2

3

0.80

0.365

Disruption of hemostasis [27]

CREGF

1

1

0.01

0.007

Substrate recognition and specificity [28]

HYAL

1

1

0.20

0.089

Degradation of extracellular matrix and

connective tissue; spreading factor [29]

LAAO

1

3

0.88

0.403

Edema, platelet aggregation, and apoptosis

due to the liberation of peroxides [30]

NP

1

1

0.70

0.321

Hypotension [3]

NGF

1

2

0.58

0.264

Induction of apoptosis in neuronal cells [31]

NUC

1

1

0.23

0.103

Liberation of toxic nucleosides [32]

PDE

1

1

0.11

0.052

Hydrolysis of phosphodiester bonds; hypotension [32]

PLB

1

1

0.34

0.154

Unknown; potentially hemolytic and/or cytotoxic [2, 33]

VEGF

3

3

1.05

0.479

Hypotension and augmentation of vascular permeability [34]