The venom-gland transcriptome of the eastern coral snake ( Micrurus fulvius ) reveals high venom complexity in the intragenomic evolution of venoms

Table 2 Low abundance toxin classes

Toxin class	Clusters	Sequences	% toxin reads	% total reads	Putative function
CTL	2	3	0.80	0.365	Disruption of hemostasis [27]
CREGF	1	1	0.01	0.007	Substrate recognition and specificity [28]
HYAL	1	1	0.20	0.089	Degradation of extracellular matrix and
					connective tissue; spreading factor [29]
LAAO	1	3	0.88	0.403	Edema, platelet aggregation, and apoptosis
					due to the liberation of peroxides [30]
NP	1	1	0.70	0.321	Hypotension [3]
NGF	1	2	0.58	0.264	Induction of apoptosis in neuronal cells [31]
NUC	1	1	0.23	0.103	Liberation of toxic nucleosides [32]
PDE	1	1	0.11	0.052	Hydrolysis of phosphodiester bonds; hypotension [32]
PLB	1	1	0.34	0.154	Unknown; potentially hemolytic and/or cytotoxic [2, 33]
VEGF	3	3	1.05	0.479	Hypotension and augmentation of vascular permeability [34]

Abbreviations. CTL C-type lectin, CREGF Cysteine-rich with EGF-like domain, HYAL hyaluronidase, LAAO L amino-acid oxidase, NP natriuretic peptide, NGF nerve growth factor, NUC nucleotidase, PDE phosphodiesterase, PLB phospholipase B, VEGF vascular endothelial growth factor.

ISSN: 1471-2164