The venom-gland transcriptome of the eastern coral snake (Micrurus fulvius) reveals high venom complexity in the intragenomic evolution of venoms

Table 4 Summary of codeml results

Class	n/Model	M1: Nearly neutral	−lnL	M2: Positive selection	−lnL	M0:ω	λ	p-value
3FTx	26	p: 0.27 0.73	1,600.40	p: 0.13 0.31 0.56	1,576.50	1.48	47.8	4.17 ×10⁻¹¹*
	F81+G	ω: 0.11 1.00		ω: 0.00 1.00 3.79
KUN	9	p: 0.32 0.68	965.08	p: 0.31 0.45 0.24	962.16	0.58	5.84	5.39 ×10⁻²
	GTR+G	ω: 0.02 1.00		ω: 0.03 1.00 2.74
LCN	9	p: 0.86 0.14	315.85	p: 0.84 0.00 0.16	305.84	999.00	20.02	4.49 ×10⁻⁵*
	JC+I	ω: 1.00 1.00		ω: 0.00 1.00 999.00
PLA₂	52	p: 0.66 0.34	4,761.33	p: 0.49 0.28 0.23	4,359.71	3.32	443.24	0.00*
	SYM+G	ω: 0.05 1.00		ω: 0.04 1.00 11.68

dN/dS ratios are represented by ω; λ represents our test statistic which is negative twice the difference in log likelihoods compared across models to a χ² distribution with two degrees of freedom; and p corresponds to the proportion of codon sites falling into one of three rate classes which are purifying selection, neutral selection, and positive selection, respectively. The model selected by MrModelTest2.3 [50] for the estimation of the maximum-likelihood phylogeny is given and n corresponds to the number of sequences used in the analysis. Significant p-values are indicated by an asterisk.

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