Genome-wide analysis of H4K5 acetylation associated with fear memory in mice

Park, C Sehwan; Rehrauer, Hubert; Mansuy, Isabelle M

doi:10.1186/1471-2164-14-539

BMC Genomics

Table 1 GO enrichment analysis of MACS-identified genes differentially acetylated for H4K5 in FC and control in hippocampus

From: Genome-wide analysis of H4K5 acetylation associated with fear memory in mice

GO term	Annotation	Treatment	Fold-change	P-value*
GO:0045202	Cellular component: synapse	FC	5.78	8.01E-06
GO:0000267	Cellular component: cell fraction	FC	3.48	7.33E-05
GO:0005624	Cellular component: membrane fraction	FC	3.76	0.0001
GO:0003008	Biological process: system process	FC	3.03	0.0002
GO:0015491	Molecular function: cation:cation antiporter activity	FC	26.05	0.0002
GO:0005626	Cellular component: insoluble fraction	FC	3.59	0.0002
GO:0022892	Molecular function: substrate-specific transporter activity	FC	2.81	0.0004
GO:0022891	Molecular function: substrate-specific transmembrane transporter activity	FC	2.93	0.0004
GO:0014069	Cellular component: postsynaptic density	FC	11.65	0.0004
GO:0007416	Biological process: synapse assembly	FC	18.89	0.0005
GO:0006897	Biological process: endocytosis	FC	5.74	0.0006
GO:0010324	Biological process: membrane invagination	FC	5.74	0.0006
GO:0050885	Biological process: neuromuscular process controlling balance	FC	16.85	0.0007
GO:0065008	Biological process: regulation of biological quality	FC	2.28	0.0008
GO:0050877	Biological process: neurological system process	FC	3.08	0.0008
GO:0022857	Molecular function: transmembrane transporter activity	FC	2.74	0.0008
GO:0042592	Biological process: homeostatic process	FC	2.85	0.0009
GO:0006810	Biological process: transport	FC	1.84	0.001
GO:0043062	Biological process: extracellular structure organization	FC	6.49	0.001
GO:0030424	Cellular component: axon	FC	6.38	0.0011
GO:0005583	Cellular component: fibrillar collagen	FC	39.19	0.0011
GO:0044456	Cellular component: synapse part	FC	4.92	0.0014
GO:0005246	Molecular function: calcium channel regulator activity	FC	32.07	0.0017
GO:0015075	Molecular function: ion transmembrane transporter activity	FC	2.73	0.0021
GO:0015298	Molecular function: solute:cation antiporter activity	FC	11.8	0.0021
GO:0005794	Cellular component: Golgi apparatus	FC	2.84	0.0025
GO:0015385	Molecular function: sodium:hydrogen antiporter activity	FC	26.05	0.0026
GO:0005451	Molecular function: monovalent cation:hydrogen antiporter activity	FC	26.05	0.0026
GO:0005215	Molecular function: transporter activity	FC	2.24	0.0032
GO:0005581	Cellular component: collagen	FC	19.59	0.0046
GO:0000166	Molecular function: nucleotide binding	Control	4.43	5.04E-06
GO:0032553	Molecular function: ribonucleotide binding	Control	4.31	7.57E-05
GO:0032555	Molecular function: purine ribonucleotide binding	Control	4.31	7.57E-05
GO:0017076	Molecular function: purine nucleotide binding	Control	4.15	0.0001
GO:0005524	Molecular function: ATP binding	Control	4.76	0.0001
GO:0032559	Molecular function: adenyl ribonucleotide binding	Control	4.71	0.0001
GO:0005003	Molecular function: ephrin receptor activity	Control	112.59	0.0001
GO:0050771	Biological process: negative regulation of axonogenesis	Control	90.12	0.0002
GO:0021955	Biological process: central nervous system neuron axonogenesis	Control	96.56	0.0002
GO:0001883	Molecular function: purine nucleoside binding	Control	4.47	0.0002
GO:0030554	Molecular function: adenyl nucleotide binding	Control	4.49	0.0002
GO:0001882	Molecular function: nucleoside binding	Control	4.45	0.0002
GO:0031345	Biological process: negative regulation of cell projection organization	Control	71.15	0.0004
GO:0010171	Biological process: body morphogenesis	Control	67.59	0.0004
GO:0007492	Biological process: endoderm development	Control	46.61	0.0008
GO:0021954	Biological process: central nervous system neuron development	Control	42.24	0.001
GO:0050768	Biological process: negative regulation of neurogenesis	Control	39.76	0.0011
GO:0010721	Biological process: negative regulation of cell development	Control	37.55	0.0013
GO:0021953	Biological process: central nervous system neuron differentiation	Control	32.97	0.0017
GO:0030027	Cellular component: lamellipodium	Control	26.13	0.0026
GO:0031252	Cellular component: cell leading edge	Control	15.19	0.0076
GO:0044428	Cellular component: nuclear part	Control	3.16	0.0353
GO:0042995	Cellular component: cell projection	Control	3.99	0.0379
GO:0031981	Cellular component: nuclear lumen	Control	3.91	0.0399
GO:0005667	Cellular component: transcription factor complex	Control	6.25	0.0403

Summary of GO enrichment analysis of genes differentially acetylated for H4K5 in FC over control (FC) and control over FC (Control) by MACS and using Webgestalt GO analysis.
* Sorted according to treatment followed by P-value, using Benjamini-Hochberg correction for multiple comparisons.

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ISSN: 1471-2164

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