Figure 7

H4K5Ac binding positively correlates with gene expression in the rat dorsal striatum. ChIP-Seq and expression data were compared as described previously [51]. In short, genes were sorted based on gene expression values (Z scores) and binned into groups of 100 genes. The average gene expression value for each bin was then calculated. H4K5Ac tags were assigned to the nearest promoter region of genes and normalized to the total tag counts for that sample. The mean tag counts of the above mention bins were also calculated. The averaged binned gene expression values were then graphed against mean tag counts for each bin. The values in the insets represent the regression coefficients (R²).