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Table 1 Effects of acute METH injection on gene expression and H4K5Ac binding in METH-naïve rats

From: Genome-wide profiling identifies a subset of methamphetamine (METH)-induced genes associated with METH-induced increased H4K5Ac binding in the rat striatum

Symbol

Definition

FC

H4K5Ac binding

Dusp14

Dual specificity phosphatase 14

13.17

4.35

Peli1

Pellino homolog 1 (Drosophila)

10.64

4.97

Npas4

Neuronal PAS domain protein 4

9.04

3.97

Prodh2

Proline dehydrogenase (oxidase) 2

6.95

4.24

Olr464

Olfactory receptor 464

6.51

3.71

Nr4a3

Nuclear receptor subfamily 4, group A, member 3

6.43

6.01

Fos

FBJ murine osteosarcoma viral oncogene homolog

6.18

4.77

Nr4a3

Nuclear receptor subfamily 4, group A, member 3

4.71

4.39

Egr4

Early growth response 4

4.62

*

Fzd7

Frizzled homolog 7 (Drosophila)

4.22

*

Pkp2

Plakophilin 2

3.79

NC

Nptx2

Neuronal pentraxin II

3.77

2.44

Inhba

Inhibin beta-A

3.71

*

Dhrs9

Dehydrogenase/reductase (SDR family) member 9

3.54

NC

Hcrt

Hypocretin

3.08

3.07

Egr2

Early growth response 2

3.08

3.49

Arc

Activity regulated cytoskeletal-associated protein

2.88

NC

Junb

Jun-B oncogene

2.36

*

Taar8c

Trace-amine-associated receptor 8c

2.33

*

Nts

Neurotensin

2.32

2.67

Gadd45g

Growth arrest and DNA-damage-inducible 45 gamma

2.21

5.30

Dnajb5

DnaJ (Hsp40) homolog, subfamily B, member 5

2.03

2.28

Cebpb

CCAAT/enhancer binding protein (C/EBP)

1.99

2.75

Tgfb3

Transforming growth factor, beta 3

1.98

6.55

Egr1

Early growth response 1

1.89

*

Baz1a

Bromodomain adjacent to zinc finger domain, 1A

1.89

3.13

Dusp5

Dual specificity phosphatase 5

1.84

*

Porf1

Preoptic regulatory factor 1

1.83

2.48

Per1

Period homolog 1 (Drosophila)

1.83

3.48

Ptpdc1

Protein tyrosine phosphatase domain containing 1.

1.82

4.24

Mchr1

Melanin-concentrating hormone receptor 1

1.81

3.79

Gpd1

Glycerol-3-phosphate dehydrogenase 1 (soluble).

1.80

3.70

Abcc10

ATP-binding cassette, sub-family C (CFTR/MRP)

1.78

5.25

Crem

cAMP responsive element modulator

1.77

3.34

Mafk

v-maf musculoaponeurotic fibrosarcoma oncogene family

1.77

3.21

Vgf

VGF nerve growth factor inducible

1.76

3.67

Sstr4

Somatostatin receptor 4

1.75

3.86

Gadd45b

Growth arrest and DNA-damage-inducible 45 beta

1.72

3.26

Snf1lk

SNF1-like kinase

1.72

3.07

Asb1

Ankyrin repeat and SOCS box-containing protein 1

1.71

*

Pip3ap

Phosphatidylinositol-3-phosphatase associated protein

1.70

*

Stag3

Stromal antigen 3

−1.85

*

Gpr149

G protein-coupled receptor 149

−1.85

NC

Vegfc

Vascular endothelial growth factor C

−1.90

−1.49

Jag1

Jagged 1 (Jag1), mRNA.

−1.94

−3.50

Olr990

Olfactory receptor 990 (Olr990), mRNA.

−4.34

*

Amy1

Amylase 1, salivary (Amy1), mRNA.

−4.54

*

Tshr

Thyroid stimulating hormone receptor (Tshr), mRNA.

−4.85

*

Dao1

D-amino acid oxidase 1 (Dao1), mRNA.

−4.94

NC

Plg

Plasminogen (Plg), mRNA.

−5.37

*

Olr1463

Olfactory receptor 1463 (Olr1463), mRNA.

−5.61

NC

Olr462

Olfactory receptor 462 (Olr462), mRNA.

−5.87

*

Fshr

Follicle stimulating hormone receptor (Fshr), mRNA.

−6.06

*

  1. Gene expression was measured by microarray analysis. Genes were identified as showing changes in expression if they showed greater than ±1.7-fold changes (p < 0.01) in comparison to the control group. H4K5Ac binding was measured by ChIP-Seq assays. H4K5Ac binding was calculated by comparing the control and METH-treated groups, after corrections for DNA inputs. Abbreviations: FC fold changes, NC no changes in H4K5Ac binding, *, no H4K5Ac binding sites observed.