Table 1 Top 30 frequent annotated functions of homologous protein clusters in Fav1

Total clusters

7,187

Total (GO-annotated)

4,677

65.1%

Molecular function

3,477

48.37%

1-Nucleic acid binding

241

5.15%

2-Protein kinase activity

218

4.66%

3-DNA binding

208

4.45%

4-Catalytic activity

173

3.70%

5-Calcium ion binding

158

3.38%

6-ATP binding

129

2.76%

7-Protein binding

119

2.54%

8-GTP binding

114

2.44%

9-Transporter activity

96

2.05%

10-Structural constituent of ribosome

82

1.75%

Biological process

776

16.59%

1-Metabolism

122

2.61%

2-Electron transport

88

1.88%

3-Intracellular signaling cascade

54

1.15%

4-Proteolysis and peptidolysis

48

1.03%

5-Protein folding

47

1.00%

6-Protein modification

31

0.66%

7-Cell adhesion

29

0.62%

8-Intracellular protein transport

26

0.56%

9-Carbohydrate metabolism

21

0.45%

10-Regulation of cell cycle

18

0.38%

Cellular component

424

6%

1-Ubiquitin ligase complex

68

1.45%

2-Integral to membrane

58

1.24%

3-Membrane

58

1.24%

4-Nucleus

46

0.98%

5-Intracellular

41

0.88%

6-Cytoplasm

26

0.56%

7-Cytoskeleton

24

0.51%

8-Nucleosome

16

0.34%

9-Chromatin

10

0.21%

10-Extracellular region

8

0.17%