Figure 4

Relative coverage of predicted chimeric transcripts in AML datasets. Graphs show the ratio of (C)himeric read depth to (T)otal read depth as a function of (T)otal read depth, where T is the sum of read depth due to chimeric and wild-type transcripts. Dots indicate predictions that pass manual review and validation; crosses indicate predictions that fail manual review (see text). Lines indicate chimeric read-to-contig support levels of 5, 10, 20, and 35. A) Fusion predictions in A08823. Each fusion is represented by a triangle pointing down that uses the minimum value of T from the two genes involved in the fusion, and a triangle pointing up that uses the maximum. B) PTD predictions in A08823. C) ITD predictions in A08823. D) Fusion predictions in A08878. Triangle directions are as in (A). E) PTD predictions in A08878. F) ITD predictions in A08878.