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Figure 8 | BMC Genomics

Figure 8

From: Characterization of constitutive CTCF/cohesin loci: a possible role in establishing topological domains in mammalian genomes

Figure 8

A proposed model of role of cCTCF loci in chromatin structure. CTCF, cohesin (not shown) and possibly other factors such as Znf143 and mediator [57] (not shown) mediate long-range chromatin interactions through the constitutive CTCF sites. The cCTCF-mediated interactions organize/maintain the topological domains [23] that are units of chromosome organization. In this conceptual diagram, only constitutive CTCF sites are shown (purple ovals) and the topological domains are coloured individually.

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