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Figure 7 | BMC Genomics

Figure 7

From: Transcriptional analysis of abdominal fat in genetically fat and lean chickens reveals adipokines, lipogenic genes and a link between hemostasis and leanness

Figure 7

Transcriptional regulators of DE genes controlling lipogenesis in abdominal fat of FL and LL chickens. A large number of DE lipogenic genes interact with two transcriptional regulators, SIRT2 and PPARD (A). The IPA Upstream Regulator Analysis (B) predicts that the up-regulation of SIRT2 leads to activation of five lipogeneic genes (orange-edged arrows), whereas, the predicted inhibition of PPARD would lead to down regulation (blue-edged arrows) of seven DE target genes in the FL [or up-regulation (green gene symbols) in the LL]. The predicted activation of major lipogenic genes (ALDH2, CCL13, FASN and SCD) would be blocked (blunt orange arrow) by PPARD.

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