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Table 4 Transcriptional regulators of genes that control the divergence of abdominal fatness in FL and LL chickens

From: Transcriptional analysis of abdominal fat in genetically fat and lean chickens reveals adipokines, lipogenic genes and a link between hemostasis and leanness

Symbol NCBI Entrez gene name Activation z-score P-value of overlap # Target molecules
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 0.379 1.61E-15 34
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.935 1.75E-10 25
CREB1 cAMP responsive element binding protein 1 0.527 1.64E-05 15
NR0B2 nuclear receptor subfamily 0, group B, member 2 (SHP) −0.84 3.74E-08 10
NR1H2 nuclear receptor subfamily 1, group H, member 2 (LXRB) −1.512 2.64E-10 12
NR1H3 nuclear receptor subfamily 1, group H, member 3 (LXRA) −0.2 4.69E-11 14
NR1H4 nuclear receptor subfamily 1, group H, member 4 (FXR) 1.076 1.40E-06 11
NR5A2 nuclear receptor subfamily 5, group A, member 2 (LRH1) −1.412 3.57E-04 7
PPARA peroxisome proliferator-activated receptor alpha −1.339 1.78E-32 54
PPARD peroxisome proliferator-activated receptor delta −0.767 3.13E-13 21
PPARG peroxisome proliferator-activated receptor gamma −1.629 1.38E-27 48
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 1.488 1.37E-12 12
RXRA retinoid X receptor, alpha −0.932 3.32E-18 31
SREBF1 sterol regulatory element binding transcription factor 1 0.511 2.91E-20 29
SREBF2 sterol regulatory element binding transcription factor 2 1.171 2.78E-15 17
THRA thyroid hormone receptor, alpha −0.246 2.08E-08 12
THRB thyroid hormone receptor, beta 1.135 7.18E-11 19
  1. Ingenuity Upstream Regulator Analysis® identified multiple transcription factors (mainly ligand-activated nuclear factors) controlling a greatly amplified number of lipid metabolism genes in abdominal fat during juvenile development (1–11 wk) of FL and LL chickens (see Figure 9). The activation Z-score indicates whether the observed gene responses to upstream regulators agrees with expected changes derived from the literature and accrued in the Ingenuity® Knowledge Base [42]. A Fisher’s Exact Test was used to determine the significance for enrichment of our target DE genes controlled by numerous upstream regulators and annotated in the Ingenuity® Knowledge Base.
  2. Abbreviations: small heterodimer partner (SHP), liver X receptor alpha (LXRA), liver X receptor beta (LXRB), farnesoid X nuclear receptor (FXR), and liver receptor homolog 1 (LRH1).