Figure 1
From: Transcriptional profiling reveals progeroid Ercc1-/Δ mice as a model system for glomerular aging
Overlap of differentially expressed genes in aged WT and aged Ercc1-/Δmice. (A) In aged WT glomeruli (light grey), 289 genes are differentially expressed (fold change ≥ 1.5). 322 genes are differentially expressed in aged Ercc1-/Δglomeruli (dark grey). The intersection of the two groups contains 90 genes whereas only 3.2 would have been expected by chance alone (p < 0.0001, Fisher's exact test). (B) FC-FC plot of 90 genes representing the intersection of the two groups displayed in Figure 1A. (C) 73 genes differentially expressed in young WT mice between 4 and 14 weeks of age were considered to reflect kidney development and maturation and were subtracted from the dataset of both old WT and old Ercc1-/Δglomeruli. 257 genes remained for aged WT glomeruli (light grey), and 268 genes for aged Ercc1-/Δglomeruli (dark grey). 77 genes were differentially expressed in both datasets. Only 1.19 genes would have been expected to intersect by chance alone (p < 0.0001, Fisher's exact test). (D) FC-FC plot of 77 genes representing the intersection of the two groups displayed in Figure 1C.