Figure 5

Minimal state networks of WT and Ercc1^-/Δmice. The graphs show the minimally connected interaction networks of wild type (A) and Ercc1^-/Δ(B) mice. Pink circles indicate all genes that were differentially expressed. Grey circles indicate linker genes. Both networks contain functional modules associated with chemokine receptor signaling, insulin signaling, anti-apoptotic signaling as well as extracellular matrix and complement signaling. A major component of the Ercc1^-/Δnetwork, as expected, consists of genes that are part of cell cycle regulation/mitosis. (C) Network analysis of only 77 overlapping regulated genes between WT and Ercc1^-/Δfurther illustrates similarities between WT and Ercc1^-/Δnetworks possibly reflecting aging processes.