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Table 2 Top ranking enriched gene sets in different signature groups during hibernation

From: Molecular signatures of mammalian hibernation: comparisons with alternative phenotypes

Gene set description

# Genes in set

# Overlapping genes

FDR q-value

477 genes that were over-expressed during T compared to P

Lipid and lipoprotein metabolism

478

26

3.5×10-9

Fatty acid metabolism

42

9

1.8×10-7

Valine, leucine, and isoleucine degradation

44

9

1.8×10-7

Fatty acid, triacylglycerol, and ketone body metabolism

168

14

4.9×10-7

PPAR signaling pathway

69

9

7.1×10-6

439 genes that were under-expressed during T compared to P

Lipid and lipoprotein metabolism

478

34

0

Biological oxidations

139

19

0

Drug metabolism - cytochrome P450

72

16

0

Phase II conjugation

70

15

0

301 genes that were over-expressed during A compared to P

Lipid and lipoprotein metabolism

478

14

2.7×10-3

522 genes that were under-expressed during A compared to P

Lipid and lipoprotein metabolism

478

36

0

Biological oxidations

139

29

0

Retinol metabolism

64

16

0

Phase II conjugation

70

19

0

Steroid hormone biosynthesis

55

16

0

291 genes that were over-expressed during T compared to A

RNA metabolism

330

23

0

Ribosomes

88

16

0

60S ribosomal subunit, cytoplasmic

47

13

0

92 genes that were under-expressed during T compared to A

   

HCF-1 complex

19

3

8.4×10-3

  1. Gene set enrichment analysis (v3.87) was performed with canonical gene pathways in the comparisons between torpor (T), arousal episodes (A), and post-reproduction (P).