Figure 6

A molecular interaction network during mouse organogenesis. (A) The 1000 most significantly regulated genes among the 4 major patterns shown in Figure 4 during mouse organogenesis were analyzed by using the STRING database to obtain a protein interaction network. Each line between any two proteins (dots) indicates an interaction. The genes are grouped into 4 categories based on their cellular locations. The color indicates the gene regulation patterns as in Figure 4. (B) The cell cycle sub-network showing that many interacting proteins have similar expression profiles: most genes on the left circle are down-regulated while those on the left are arch-up regulated. The size of each dot is proportional to the number of interactions the protein has within the network. (C) The neurogenesis genes subnetwork showing that the arch-down genes may function to bridge interactions among the proteins in different regulation groups in the network.