Combined genotype and haplotype tests for region-based association studies

BMC Genomics

Table 3 Replication results on Chinese samples from the Singapore Indian Chinese cohort eye study

	COL8A2	ZNF469-LOC100128913	RXRA-COL5A1	COL8A2- TRAPPC3	C7orf42
Genotype SKAT	0.019	0.117	0.001	1	0.014
Haplotype SKAT	0.599	0.479	0.1	1	0.27
MinP-val	0.037	0.223	0.002	0.989	0.028
SumP-val	0.089	0.186	0.001	0.788	0.027
Single-SNP analysis*	rs96067: 0.036	rs9938149: 0.4 rs12447690: 0.03	rs1536478: 0.016	-	-

Significant p-values are shown in bold. For single-SNP analysis the Bonferroni correction corresponds to the four tests. * Trend test within a linear regression model.

ISSN: 1471-2164