Figure 4

Lipid synthesis and metabolism pathways regulated by RA treatment and RXRα deficiency. The diagram represents the effect of RA treatment and RXRα deficiency on the expression of 114 lipid genes based on PCA analysis. Fifty-five genes were induced by RA and inhibited due to the lack of RXRα, and fifty-nine of them were induced because of RXRα deficiency and RA suppressing. Gene functions were obtained from the KEGG database and confirmed in PubMed gene database. The arrows inside the circle represent the lipid synthesis processes, and the outer arrows represent the lipid elimination processes. The “T” sign represents inhibition and all arrows represent inductions.